Mechanisms of Toxic Effect of Streptozotocin on β-Cells in the Islets of Langerhans
| Autor: | Alexander A. Spasov, M. P. Samokhina, G. L. Snigur, V. B. Pisarev, A. E. Bulanov |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Antioxidant endocrine system diseases medicine.medical_treatment Apoptosis Streptozocin General Biochemistry Genetics and Molecular Biology Islets of Langerhans Insulin-Secreting Cells Internal medicine medicine Animals Cytotoxic T cell Caspase geography geography.geographical_feature_category biology Chemistry Pancreatic islets General Medicine Islet Streptozotocin Rats Endocrinology medicine.anatomical_structure Caspases biology.protein Blood sugar regulation DNA Damage medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 148:937-939 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-010-0856-9 |
| Popis: | Administration of streptozotocin caused selective damage to endocrine β-cells in rat pancreatic islets, which was related to activation of apoptosis. The cytotoxic effect of streptozotocin was associated not only with DMA damage due to dysfunction of the antioxidant defense system, but also with activation of the caspase cascade and TNF-related apoptosis-inducing ligand. |
| Databáze: | OpenAIRE |
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