Drug shortages in a pediatric stem cell transplantation ward: Challenges and implications. A 5-year bilan
| Autor: | Tieneke Bauters, Genevieve Laureys, Barbara Claus |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pharmacies
Drug medicine.medical_specialty business.industry media_common.quotation_subject Hematopoietic Stem Cell Transplantation Hematopoietic stem cell Economic shortage Transplantation 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Pharmaceutical Preparations Oncology 030220 oncology & carcinogenesis medicine Humans Pharmacology (medical) Stem cell Child Intensive care medicine business 030215 immunology media_common |
| Zdroj: | Journal of Oncology Pharmacy Practice. 25:841-846 |
| ISSN: | 1477-092X 1078-1552 |
| DOI: | 10.1177/1078155218765627 |
| Popis: | This article describes the implications of shortages of pharmaceutical products used in conditioning and supportive care regimens of pediatric patients undergoing a hematopoietic stem cell transplantation in a tertiary care hospital. Between July 2011 and July 2016, a total of 84 individual shortages, affecting 22 different drugs (79.8% supportive care drugs; 20.2% chemotherapeutics) were detected with a mean duration of 85 days (SD 138) per individual drug shortage. Eighteen shortages were critical and very urgent. Sulfamethoxazol/trimethoprim, piperacillin/tazobactam, ranitidine, benzylpenicillin, ondansetron (supportive care) and methotrexate, melphalan (chemotherapeutics) had the longest supply disruptions. A variety of solutions could be identified including the purchase of a generic alternative (36.9%) for both oral and parenteral treatments (in a ratio 3:2). Urgent import from another (European) country was performed in 14 cases (16.7%). High impact solutions such as cohorting of patients and change of ongoing treatments (2.4%) were used for parenteral treatments only. Pharmaceutical modification was sometimes applied for oral treatments (2.4%). Due to persistent occurrence of these shortages, an efficient pharmacy workflow (electronic follow-up by end of 2016) and a multidisciplinary approach were needed. |
| Databáze: | OpenAIRE |
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