Metals and Neurodegeneration
Autor: | Mahfuzur R. Miah, Pan Chen, Michael Aschner |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Parkinson's disease Cognitive Neuroscience Neurodevelopment neurological disorders Review Disease Toxicology medicine.disease_cause Neurobiology of Disease & Regeneration General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Huntington's disease medicine General Pharmacology Toxicology and Pharmaceutics Amyotrophic lateral sclerosis Neurogenetics Motor Systems Neuronal & Glial Cell Biology Movement Disorders General Immunology and Microbiology business.industry Multiple sclerosis Neurodegeneration neurodegeneration Articles General Medicine medicine.disease metal accumulation 3. Good health 030104 developmental biology Cognitive Neurology & Dementia Immunology Parkinson’s disease Autism business Alzheimer’s disease 030217 neurology & neurosurgery Oxidative stress Control of Gene Expression Membranes & Sorting Huntington’s disease |
Zdroj: | F1000Research |
ISSN: | 2046-1402 |
Popis: | Metals play important roles in the human body, maintaining cell structure and regulating gene expression, neurotransmission, and antioxidant response, to name a few. However, excessive metal accumulation in the nervous system may be toxic, inducing oxidative stress, disrupting mitochondrial function, and impairing the activity of numerous enzymes. Damage caused by metal accumulation may result in permanent injuries, including severe neurological disorders. Epidemiological and clinical studies have shown a strong correlation between aberrant metal exposure and a number of neurological diseases, including Alzheimer’s disease, amyotrophic lateral sclerosis, autism spectrum disorders, Guillain–Barré disease, Gulf War syndrome, Huntington’s disease, multiple sclerosis, Parkinson’s disease, and Wilson’s disease. Here, we briefly survey the literature relating to the role of metals in neurodegeneration. |
Databáze: | OpenAIRE |
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