Metals and Neurodegeneration

Autor: Mahfuzur R. Miah, Pan Chen, Michael Aschner
Rok vydání: 2016
Předmět:
0301 basic medicine
Parkinson's disease
Cognitive Neuroscience
Neurodevelopment
neurological disorders
Review
Disease
Toxicology
medicine.disease_cause
Neurobiology of Disease & Regeneration
General Biochemistry
Genetics and Molecular Biology

03 medical and health sciences
0302 clinical medicine
Huntington's disease
medicine
General Pharmacology
Toxicology and Pharmaceutics

Amyotrophic lateral sclerosis
Neurogenetics
Motor Systems
Neuronal & Glial Cell Biology
Movement Disorders
General Immunology and Microbiology
business.industry
Multiple sclerosis
Neurodegeneration
neurodegeneration
Articles
General Medicine
medicine.disease
metal accumulation
3. Good health
030104 developmental biology
Cognitive Neurology & Dementia
Immunology
Parkinson’s disease
Autism
business
Alzheimer’s disease
030217 neurology & neurosurgery
Oxidative stress
Control of Gene Expression
Membranes & Sorting
Huntington’s disease
Zdroj: F1000Research
ISSN: 2046-1402
Popis: Metals play important roles in the human body, maintaining cell structure and regulating gene expression, neurotransmission, and antioxidant response, to name a few. However, excessive metal accumulation in the nervous system may be toxic, inducing oxidative stress, disrupting mitochondrial function, and impairing the activity of numerous enzymes. Damage caused by metal accumulation may result in permanent injuries, including severe neurological disorders. Epidemiological and clinical studies have shown a strong correlation between aberrant metal exposure and a number of neurological diseases, including Alzheimer’s disease, amyotrophic lateral sclerosis, autism spectrum disorders, Guillain–Barré disease, Gulf War syndrome, Huntington’s disease, multiple sclerosis, Parkinson’s disease, and Wilson’s disease. Here, we briefly survey the literature relating to the role of metals in neurodegeneration.
Databáze: OpenAIRE