Retrospective analysis of the risk factors for linezolid-induced thrombocytopenia in adult Japanese patients
| Autor: | Yuichi Sakamoto, Motoki Ohnishi, Naoki Tachibana, Ryuichi Hirano |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Pharmaceutical Science Renal function Platelet Transfusion Pharmacy Infections Toxicology Tertiary Care Centers chemistry.chemical_compound Anti-Infective Agents Japan Risk Factors Internal medicine Acetamides medicine Humans Pharmacology (medical) Renal Insufficiency Adverse effect Oxazolidinones Aged Retrospective Studies Aged 80 and over Pharmacology Platelet Count business.industry Incidence Incidence (epidemiology) Age Factors Linezolid Retrospective cohort study Odds ratio Middle Aged Hospitals District Thrombocytopenia Confidence interval Surgery Platelet transfusion chemistry Female business |
| Zdroj: | International Journal of Clinical Pharmacy. 36:795-799 |
| ISSN: | 2210-7711 2210-7703 |
| DOI: | 10.1007/s11096-014-9961-6 |
| Popis: | Background Thrombocytopenia is a major side effect of linezolid therapy. However, there are few reports about the risk factors for linezolid-induced thrombocytopenia. Objective The aim of this study is to evaluate the risk factors for thrombocytopenia in patients who undergo linezolid therapy. Setting Aomori Prefectural Central Hospital in Japan, a tertiary 695 beds hospital. Method A retrospective review was performed using the hospital’s medical records. From January 2010 to August 2012, 75 adult patients who received linezolid therapy were enrolled in this study. Main outcome measure Linezolid-induced thrombocytopenia was defined as a decrease in the patient’s platelet count to |
| Databáze: | OpenAIRE |
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