Changes in the haematopoietic progenitor cell compartment in the acquired immunodeficiency syndrome
| Autor: | B. Völkers, H. von Briesen, Oliver G. Ottmann, Dieter Hoelzer, H. Rübsamen-Waigmann, Arnold Ganser |
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| Rok vydání: | 1990 |
| Předmět: |
CD4-Positive T-Lymphocytes
Immunology AIDS-related complex Bone Marrow Cells In situ hybridization In Vitro Techniques Biology T-Lymphocytes Regulatory Peripheral blood mononuclear cell AIDS-Related Complex Bone Marrow Virology medicine Humans Lymphocytes Progenitor cell Acquired Immunodeficiency Syndrome Antibodies Monoclonal Hematopoietic Stem Cells medicine.disease Hematopoiesis Haematopoiesis medicine.anatomical_structure Cell culture Bone marrow CD8 |
| Zdroj: | Research in Virology. 141:185-193 |
| ISSN: | 0923-2516 |
| Popis: | In order to elucidate the mechanisms responsible for the disturbances of haematopoiesis in HIV-infected individuals, bone marrow from 25 patients with either ARC or AIDS was studied. There is a stage-related decrease in CFU-GEMM, CFU-MK, BFU-E and CFU-GM, with the latter being least affected. This decrease is inversely correlated with the number of circulating CD4 cells and the CD4/CD8 ratio. Immunohistochemical and in situ hybridization studies of haematopoietic colonies failed to demonstrate HIV infection of haematopoietic cells. Neither the depletion of adherent mononuclear cells from haematopoietic cell cultures nor the addition of plasma containing antibodies against HIV gp120 could demonstrate an inhibitory effect of HIV-infected macrophages or immune-mediated progenitor cell lysis, respectively. Hence, imbalances of T-cell subpopulations appear to be mainly responsible for the progressive impairment of proliferation and differentiation of bone marrow progenitor cells observed in HIV-infected individuals. |
| Databáze: | OpenAIRE |
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