Oral administration of vitamin D and importance in prevention of cerebral malaria
| Autor: | Yunting Du, Yang Liu, Yaming Cao, Yonghui Feng, Qinghui Wang, Wei Pang, Zanmei Qi, Ji-chun Wang, Bo Wu, Dan Yang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Plasmodium berghei Immunology Malaria Cerebral Administration Oral Proinflammatory cytokine Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Cell Movement Oral administration parasitic diseases Cell Adhesion Vitamin D and neurology Animals Immunology and Allergy Medicine 030212 general & internal medicine Vitamin D Pharmacology biology business.industry Brain Th1 Cells biology.organism_classification medicine.disease Interleukin-10 Mice Inbred C57BL 030104 developmental biology chemistry Cerebral Malaria Dietary Supplements Female business Cholecalciferol Malaria |
| Zdroj: | International Immunopharmacology. 64:356-363 |
| ISSN: | 1567-5769 |
| DOI: | 10.1016/j.intimp.2018.08.041 |
| Popis: | Cerebral malaria (CM) is a serious and fatal malaria-associated syndrome caused by the development of an overwhelming proinflammatory response. Vitamin D (Vit.D; cholecalciferol) has regulatory functions associated with both innate and adaptive immune responses. Prevention is better than cure, in this experiment, we evaluated prophylactic oral Vit.D as a means of preventing CM presentation before infection of C57BL/6 mice with Plasmodium berghei ANKA (PbA) by modulating the host proinflammatory response. Mice that were supplemented with oral Vit.D has reduce death rate and ameliorated the integrity of the blood brain barrier. Prophylactic oral vitamin D relieved the symptoms of brain malaria and avoided death, gained valuable time for the diagnosis and treatment post infection. The robust Th1 response was attenuated in the Vit.D + PbA group. Furthermore, T-cell trafficking to the brain was diminished before PbA infection using Vit.D. The results suggest that Vit.D supplementation mediates the development of an anti-inflammatory environment that improves CM severity. In summary, the use of Vit.D as a nutritional supplement in malaria-endemic regions may help reduce the severity and mortality of CM. |
| Databáze: | OpenAIRE |
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