Distribution of SC-4453, a new semi-synthetic derivative of digoxin, following an infusion preceded by an i.v. loading dose in the guinea-pig. Binding to plasma proteins
| Autor: | F. Randimbivololona |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_specialty
Digoxin Guinea Pigs Loading dose Guinea pig Cardiac Glycosides Internal medicine medicine Distribution (pharmacology) Animals Pharmacology (medical) Tissue Distribution Pharmacology Chromatography Chemistry Skeletal muscle Metabolism Blood Proteins Blood proteins Endocrinology medicine.anatomical_structure Injections Intravenous Steady state (chemistry) medicine.drug Protein Binding |
| Zdroj: | European journal of drug metabolism and pharmacokinetics. 13(1) |
| ISSN: | 0378-7966 |
| Popis: | The tissue distribution of 12 alpha-[3H]SC-4453 was studied in the guinea-pig after a 15 hours infusion at the rate of 4 micrograms/h/kg, preceded by an IV loading dose. At the end of the infusion, at the steady state, the skeletal muscle apparently presented the highest concentration of SC-4453 (24 ng/g) and the brain the lowest (1.2 ng/g), which demonstrates the presence of a blood-brain barrier to this compound. Our results also show that this new semi-synthetic cardiotonic presents a weak affinity to plasma proteins (25%). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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