General Pharmacology in Experimental Animals of Gadobenate Dimeglumine (MultiHance®), a New Magnetic Resonance Imaging Contrast Agent
| Autor: | A. La Noce, C. De Haen, V. Frigeni, Piervitto Cipolla, P. Tirone, R. Valenti, Mauro Castano, Franco Luzzani |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Cardiac output Swine Guinea Pigs Myocardial Ischemia Contrast Media Diuresis Hemodynamics Gadolinium Pharmacology Kidney Drug Hypersensitivity Rats Sprague-Dawley Contractility Meglumine Organometallic Compounds medicine Animals Radiology Nuclear Medicine and imaging Lung Mononuclear Phagocyte System business.industry Heart Magnetic Resonance Imaging Rats Blood pressure medicine.anatomical_structure Liver Blood-Brain Barrier Injections Intravenous Circulatory system Vascular resistance Swine Miniature Liver function business |
| Zdroj: | Journal of Computer Assisted Tomography. 23:S195-S206 |
| ISSN: | 0363-8715 |
| DOI: | 10.1097/00004728-199911001-00024 |
| Popis: | Objectives: To assess in animals the pharmacological tolerability for intravascular gadobenate dimeglumine. Results: Cardiovascular effects: In healthy animals no relevant effects were observed apart from slight and transient increases in cardiac output and decreases in systemic vascular resistance. In pigs with myocardial ischemia: doses up to 3.0 mmol/kg caused dose-dependent decreases in heart rate, systemic vascular resistance and mean arterial blood pressure along with transient increases in cardiac output. In vitro: Myocardial contractility was slightly depressed after direct exposure to a 30 mM solution. Respiratory effects in healthy pigs: no effects after 1.0 mmol/kg i.v. Effects on the central nervous system: In healthy animals: gadobenate dimeglumine, 1.0 mmol/kg i.v, did not penetrate nor impair the blood-brain barrier in rats and did not affect behavior, motor coordination or EEG. In pathological models: even in the presence of an osmotically disrupted blood-brain barrier, brain penetration of gadobenate was poor and no signs of epileptogenic potential were evident. Effects on blood: No hemolytic potential was observed. Plasma coagulation was slightly affected in vitro but not in vivo. Effects on kidney and liver function: Transient increases in diuresis, without effects on blood and urine enzymes were observed at doses of 1.25 and 2.5 mmol/kg. Conclusions: The clinical use of gadobenate dimeglumine as an intravascular magnetic resonance imaging contrast agent is strongly supported by the good tolerability of the product in healthy and patholological animal models. |
| Databáze: | OpenAIRE |
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