A gland of diverse pathology and unpredictable behaviour: our experience of primary submandibular gland malignancies
| Autor: | Dharma Ram, Suhas Kodasoge Rajappa, S. Dabas, Yogendra Singh Bhakuni, Ajay K. Dewan, A.K. Dewan, R. Ranjan, Himanshu Shukla |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Multivariate analysis Adenoid cystic carcinoma medicine.medical_treatment Perineural invasion 03 medical and health sciences 0302 clinical medicine Risk Factors Mucoepidermoid carcinoma Internal medicine medicine Humans Neoplasm Metastasis 030223 otorhinolaryngology Aged Retrospective Studies Unpredictable behaviour business.industry Mean age Middle Aged Prognosis medicine.disease Submandibular gland Submandibular Gland Neoplasms Survival Rate Radiation therapy medicine.anatomical_structure Otorhinolaryngology Lymphatic Metastasis 030220 oncology & carcinogenesis Female Surgery Neoplasm Grading Neoplasm Recurrence Local Oral Surgery business |
| Zdroj: | International Journal of Oral and Maxillofacial Surgery. 47:1243-1249 |
| ISSN: | 0901-5027 |
| DOI: | 10.1016/j.ijom.2018.05.012 |
| Popis: | Submandibular gland tumours are relatively uncommon tumours and demonstrate diverse histological types and a variable prognosis. The aim of this study was to analyze our experience with submandibular malignancies over a period of 6 years (January 2009 to December 2015). Patient data from the 6-year period were reviewed retrospectively and 51 patients with submandibular malignancies were identified. Demographic data, clinicopathological details, treatment received, complications, and follow-up were recorded. The mean age of the 51 patients at presentation was 49.1 years. They were followed up for a mean 20.3 months. Nine of 47 patients (19.1%) developed distant metastasis during follow-up, while only three (6.4%) developed local recurrence. Disease-free survival at 2 years was 69.7% and overall survival at the end of 2 years was 77.8%. Actuarial 5-year survival was 57.8% when all subtypes were considered. The overall mean time to recurrence was 10 months (6–24 months). Nodal positivity was the only prognostic factor that was significant on multivariate analysis, while age, sex, perineural invasion, and grade were not. With advances in surgical and radiotherapy techniques, loco-regional control rates have improved greatly; however, effective adjuvant treatment to prevent systemic relapse is still lacking. |
| Databáze: | OpenAIRE |
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