Magnetic resonance imaging of normal and osteoarthritic trabecular bone structure in the human knee
| Autor: | David C. Newitt, Sharmila Majumdar, Thomas M. Link, Olivier Beuf, Lynne S. Steinbach, Michael D. Ries, Srinka Ghosh, Nancy E Lane |
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| Přispěvatelé: | RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Imagerie moléculaire et fonctionnelle: de la physiologie à la thérapie, Université Bordeaux Segalen - Bordeaux 2-IFR8-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Méthodes et systèmes en IRM et optique musculoskeletal diseases genetic structures [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging Immunology Osteoarthritis Knee Joint Severity of Illness Index 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Rheumatology Arthropathy categₛt2i medicine Humans Immunology and Allergy Pharmacology (medical) In patient Femur Tibia ComputingMilieux_MISCELLANEOUS Aged 030203 arthritis & rheumatology medicine.diagnostic_test business.industry Reproducibility of Results Magnetic resonance imaging Anatomy Middle Aged Osteoarthritis Knee musculoskeletal system medicine.disease Magnetic Resonance Imaging imagerie_RMNₒptique reseau_international Trabecular bone Female business |
| Zdroj: | Arthritis and Rheumatism Arthritis and Rheumatism, Wiley, 2002, 46 (2), pp.385-393. ⟨10.1002/art.10108⟩ |
| ISSN: | 1529-0131 0004-3591 |
| DOI: | 10.1002/art.10108 |
| Popis: | Objective To use high-resolution magnetic resonance imaging (MRI) to evaluate the trabecular bone structure in the distal femur and the proximal tibia and its to correlate the findings with different stages of osteoarthritis (OA) of the human knee. Methods Axial images of the distal femur and proximal tibia were obtained at 1.5 T in patients without and with mild OA and with severe OA. The spatial resolution was 195 × 195 μm2 with a 1-mm slice thickness. Apparent measures of trabecular bone volume fraction (BV/TV), trabecular number (Tb.N), trabecular separation (Tb.Sp), and trabecular thickness (Tb.Th) were calculated. Results Significant differences existed in the trabecular bone structure of the femur and tibia. Differences in trabecular bone structure between the tibia and the femur decreased with the degree of OA. The apparent BV/TV, Tb.N, and Tb.Sp in the femoral condyles could be used to differentiate healthy patients or patients with mild OA from patients with severe OA (P < 0.05). Among individuals, the structural variation of the lateral and medial femoral condyle was indicative of the extent of the disease. Conclusion High-resolution MRI of the knee joint can provide a noninvasive assessment of trabecular bone structure. Trabecular bone structure, determined by high-resolution MRI, shows significant variation in patients with varying degrees of OA. The impact of OA on trabecular bone is different in the tibia than in the femur, and this difference depends on the extent of the disease. |
| Databáze: | OpenAIRE |
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