Cut-off value of D. pteronyssinus specific IgE in double negative patients Der p 1 and Der p 2 and its clinical repercussion
| Autor: | Antonio Letrán, Ignacio García, Marisa Espinazo-Romeu, Carmen Moreno-Aguilar, Francisco Moreno |
|---|---|
| Přispěvatelé: | [Letrán,A, Moreno,F] Servicio de Alergología e Inmunología, CM ASISA Lobatón, Cádiz, Spain. [García,I] University of Cordoba, Cordoba, Spain. [Espinazo-Romeu,M, Moreno-Aguilar,C] GC01 Laboratorio de Inmunología y Alergia, Maimonides Biomedical Research Institute of Cordoba (IMIBIC)/Reina Sofa University Hospital/University of Cordoba, Córdoba, Spain. [Espinazo-Romeu,M, Moreno-Aguilar,C] National Network ARADyAL, Health Institute Carlos III, Madrid, Spain. [Moreno-Aguilar,C] Department of Immunology and Allergy, Reina Sofa University Hospital, Cordoba, Spain. |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Antígenos dermatofagoides Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Globulins::Serum Globulins::Immunoglobulins::Antibodies::Immunoglobulin Isotypes::Immunoglobulin E [Medical Subject Headings] Diseases::Otorhinolaryngologic Diseases::Nose Diseases::Rhinitis [Medical Subject Headings] Science Dermatophagoides pteronyssinus Immunology Diseases Article Arthropod Proteins Organisms::Eukaryota::Animals [Medical Subject Headings] Animals Humans Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Arthropod Proteins [Medical Subject Headings] Diseases::Immune System Diseases::Hypersensitivity::Hypersensitivity Immediate::Respiratory Hypersensitivity::Asthma [Medical Subject Headings] Inmunoterapia Antigens Dermatophagoides Persons::Persons::Age Groups::Adult [Medical Subject Headings] Chemicals and Drugs::Biological Factors::Antigens::Antigens Dermatophagoides [Medical Subject Headings] Asma Rinitis Rhinitis Skin Tests Multidisciplinary Pyroglyphidae Organisms::Eukaryota::Animals::Invertebrates::Arthropods::Arachnida::Acari::Mites::Pyroglyphidae [Medical Subject Headings] Allergens Immunoglobulin E Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Cysteine Proteases [Medical Subject Headings] Rhinitis Allergic Asthma Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Immunologic Tests::Skin Tests [Medical Subject Headings] Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings] Cysteine Endopeptidases Organisms::Eukaryota::Animals::Invertebrates::Arthropods::Arachnida::Acari::Mites::Pyroglyphidae::Dermatophagoides pteronyssinus [Medical Subject Headings] Cross-Sectional Studies Inmunoglobulina E Medicine Female Immunotherapy Chemicals and Drugs::Biological Factors::Antigens::Allergens [Medical Subject Headings] |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Accessibility to more precise diagnostic techniques such as component resolved diagnostics (CRD), provides us with an important advance in diagnostic aspects as well as treatment. The subject of this study aims to better understand the profiles of sensitization to Der p 1, Der p 2 and Der p 23 and to know to what extent their use could help us in optimizing the decision-making for their treatment with Specific Immunotherapy. Cross-sectional study of subjects older than 5 years, diagnosed with allergy to HDM using skin prick test and sIgE, with symptoms of rhinitis and/or asthma. Total and specific IgE was determined to D. pteronyssinus, nDer p 1, rDer p 2 and rDer p 23 using ImmunoCAP. 240 patients were recruited (97.1% rhinitis and 46.25% rhinitis and asthma). Four different phenotypes were observed: positive or negative for sIgE nDer p 1 and/or IgE rDer p 2. 17% of these patients sIgE were double negative for Der p 1 and Der p 2 (increasing with age and with significantly lower sIgE levels than the rest of the groups). Using ROC curves, value less than 2.18 KUA/L for D. pteronyssinus sIgE gave us a sensitivity and specificity of 0.882 and 0.985, respectively, to double negative IgE nDer p 1 and IgE rDer p 2 group. Despite positive SPT and sIgE to D. pteronyssinus, 17% of the studied population is IgE nDer p 1 and IgE rDer p 2 double negative, with a cut-off value of 2.18 KU/L, which is very relevant for taking of decisions in prescription of AIT. The double positive population sIgE nDer p 1 and IgE rDer p 2 is associated with asthma compared to the other groups and this does not seem to be influenced by IgE rDer p 23. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|