Differential expression and anti-oxidant function of glutathione peroxidase 3 in mouse uterus during decidualization
| Autor: | Jing-Yu Leng, Zhirong Zhang, Yi-Juan Zhang, Ming Li, Ai-Guo Sha, Wenbo Deng, Fei Gao, Xiu Xu, Zeng-Ming Yang, Zhen-Ao Zhao, Xiao-Huan Liang |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Stromal cell Antioxidant Transcription Genetic GPX3 medicine.medical_treatment Biophysics Selenic Acid Biochemistry Antioxidants Gene Expression Regulation Enzymologic Mice Corpus Luteum Pregnancy Structural Biology Internal medicine Decidua Genetics medicine Animals Humans Decidual cells Embryo Implantation Molecular Biology Progesterone chemistry.chemical_classification Glutathione Peroxidase Thiomalates Reactive oxygen species Glutathione peroxidase Uterus Decidualization Hydrogen Peroxide Cell Biology Hypoxia-Inducible Factor 1 alpha Subunit Implantation Cell Hypoxia Endocrinology medicine.anatomical_structure chemistry Female Oxidation-Reduction Gpx3 |
| Zdroj: | FEBS Letters. 588:1580-1589 |
| ISSN: | 0014-5793 |
| Popis: | Glutathione peroxidase 3 (GPX3) is an important member of antioxidant enzymes for reducing reactive oxygen species and maintaining the oxygen balance. Gpx3 mRNA is strongly expressed in decidual cells from days 5 to 8 of pregnancy. After pregnant mice are treated with GPX inhibitor for 3days, pregnancy rate is significantly reduced. Progesterone stimulates Gpx3 expression through PR/HIF1α in mouse endometrial stromal cells. In the decidua, the high level of GPX3 expression is closely associated with the reduction of hydrogen peroxide (H2O2). Based on our data, GPX3 may play a major role in reducing H2O2 during decidualization. |
| Databáze: | OpenAIRE |
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