Penetration of moxifloxacin and levofloxacin into cancellous and cortical bone in patients undergoing total hip arthroplasty
| Autor: | A. Theodoridou, Pavlos Nikolaidis, Simeon Metallidis, Georgia Lazaraki, D. Topsis, E. Alexiadou, L. Grovaris, John Nikolaidis |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Ofloxacin medicine.medical_treatment Arthroplasty Replacement Hip Moxifloxacin Levofloxacin Microbial Sensitivity Tests Prosthesis Bone and Bones Medicine Humans heterocyclic compounds Pharmacology (medical) Chromatography High Pressure Liquid Antibacterial agent Pharmacology Aza Compounds business.industry Osteomyelitis biochemical phenomena metabolism and nutrition Middle Aged bacterial infections and mycoses medicine.disease Arthroplasty Surgery Anti-Bacterial Agents Infectious Diseases medicine.anatomical_structure Oncology Injections Intravenous Quinolines Cortical bone Female Osteitis business medicine.drug Fluoroquinolones |
| Zdroj: | Journal of chemotherapy (Florence, Italy). 19(6) |
| ISSN: | 1120-009X |
| Popis: | Penetration of levofloxacin and moxifloxacin into cancellous and cortical bone was studied using high-performance liquid chromatography (HPLC) in 16 patients who underwent routine total hip arthroplasty. Our results demonstrate a good degree of penetration into bone for both quinolones. The mean cancellous penetration was 53.86% for moxifloxacin and 54.13% for levofloxacin. The penetration into cortical bone was 41.59% and 34.26% respectively. The concentrations for both quinolones were above the minimum inhibitory concentration (MIC(90s)) for the most common pathogens, so they can be used for the treatment of osteomyelitis. |
| Databáze: | OpenAIRE |
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