A chimeric dengue virus vaccine candidate delivered by high density microarray patches protects against infection in mice
| Autor: | David A. Muller, Paul R. Young, Jessica J. Harrison, Connor A. P. Scott, Daniel Watterson, Jovin J Y Choo, Jody Hobson-Peters, Alexandra C. I. Depelsenaire, Laura J. Vet, Germain J. P. Fernando, Christopher L. D. McMillan, Roy A. Hall |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Live attenuated vaccines viruses Immunology Dengue virus medicine.disease_cause Article Virus Dengue fever 03 medical and health sciences 0302 clinical medicine medicine Pharmacology (medical) 030212 general & internal medicine Neutralizing antibody RC254-282 Pharmacology Inactivated vaccines biology Immunogenicity Neoplasms. Tumors. Oncology. Including cancer and carcinogens virus diseases RC581-607 biochemical phenomena metabolism and nutrition biology.organism_classification medicine.disease Virology Vaccination Flavivirus 030104 developmental biology Infectious Diseases Immunization biology.protein Immunologic diseases. Allergy |
| Zdroj: | npj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021) NPJ Vaccines |
| ISSN: | 2059-0105 |
| Popis: | Dengue viruses (DENV) cause an estimated 390 million infections globally. With no dengue-specific therapeutic treatment currently available, vaccination is the most promising strategy for its control. A wide range of DENV vaccines are in development, with one having already been licensed, albeit with limited distribution. We investigated the immunogenicity and protective efficacy of a chimeric virus vaccine candidate based on the insect-specific flavivirus, Binjari virus (BinJV), displaying the structural prM/E proteins of DENV (BinJ/DENV2-prME). In this study, we immunized AG129 mice with BinJ/DENV2-prME via a needle-free, high-density microarray patch (HD-MAP) delivery system. Immunization with a single, 1 µg dose of BinJ/DENV2-prME delivered via the HD-MAPs resulted in enhanced kinetics of neutralizing antibody induction when compared to needle delivery and complete protection against mortality upon virus challenge in the AG129 DENV mouse model. |
| Databáze: | OpenAIRE |
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