Immunomodulator Galectin-9 is Increased in Blood and Skin of Patients with Bullous Pemphigoid
| Autor: | Detlef Zillikens, Wiebke Pruessmann, Nina van Beek, Jasper Pruessmann, Enno Schmidt, Christoph M. Hammers, Christian D. Sadik, Maike M. Holtsche, Beke Linnemann |
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| Rok vydání: | 2021 |
| Předmět: |
bullous pemphigoid
Galectins autoimmune disease Dermatology Pathogenesis Disease activity Dermis immune system diseases Pemphigoid Bullous medicine Humans Immunologic Factors eosinophil skin and connective tissue diseases Galectin Skin Autoimmune disease integumentary system business.industry General Medicine Eosinophil medicine.disease galectin- 9 Disease area eye diseases Eosinophils medicine.anatomical_structure RL1-803 Immunology Bullous pemphigoid sense organs business |
| Zdroj: | Acta Dermato-Venereologica, Vol 101, Iss 3, p adv00419 (2021) |
| ISSN: | 1651-2057 |
| Popis: | Massive recruitment of eosinophils into the dermis is a hallmark of bullous pemphigoid pathogenesis. Identifying the chemoattractant(s) guiding eosinophils into the skin in bullous pemphigoid is a prerequisite to thera-peutic targeting of eosinophil recruitment. Galectin -9 is a potent chemoattractant for eosinophils, but its potential role in bullous pemphigoid is unknown. The aim of this study was to determine the expression levels of galectin-9 in serum and skin of patients with bullous pemphigoid. Galectin-9 levels were significantly elevated in serum of patients with bullous pemphigoid compared with age- and sex-matched controls, but did not correlate with disease activity assessed with the Bullous Pemphigoid Disease Area Index. Galectin-9 expression was also increased in lesional skin of patients with bullous pemphigoid, and was expressed predominantly in eosinophils, neutrophils and keratinocytes. In conclusion, these results support the notion that galectin-9 may play a role in the patho-genesis of bullous pemphigoid. |
| Databáze: | OpenAIRE |
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