Making, Exporting, and Modulating Wnts
| Autor: | Jean-Paul Vincent, Satoshi Kakugawa, Paul F. Langton |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Wnt signaling pathway Cell Biology Biology Models Biological Hedgehog signaling pathway Transport protein Cell biology Fatty Acids Monounsaturated Wnt Proteins Protein Transport 03 medical and health sciences 030104 developmental biology Signalling Extracellular Animals Humans Protein Processing Post-Translational Wnt Signaling Pathway Secretory pathway Function (biology) Tissue homeostasis |
| Zdroj: | Langton, P F, Kakugawa, S & Vincent, J-P 2016, ' Making, Exporting, and Modulating Wnts ', Trends in Cell Biology, vol. 26, no. 10, pp. 756-765 . https://doi.org/10.1016/j.tcb.2016.05.011 |
| ISSN: | 0962-8924 |
| DOI: | 10.1016/j.tcb.2016.05.011 |
| Popis: | Wnt proteins activate a conserved signalling pathway that controls development and tissue homeostasis in all metazoans. The intensity of Wnt signalling must be tightly controlled to avoid diseases caused by excess or ectopic signalling. Over the years, many proteins dedicated to Wnt function have been identified, including Porcupine, which appends a palmitoleate moiety that is essential for signalling activity. This lipid inevitably affects subcellular trafficking and solubility, as well as providing a target for post-translational modulation. We review here the life history of Wnts, starting with progression through the secretory pathway, continuing with release and spread in the extracellular space, and finishing with the various proteins that dampen or inactivate Wnts in the extracellular space. |
| Databáze: | OpenAIRE |
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