Heart-specific expression of FGF-16 and a potential role in postnatal cardioprotection
Autor: | David P. Sontag, Jie Wang, Peter A. Cattini |
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Rok vydání: | 2014 |
Předmět: |
Male
medicine.medical_specialty Cardiotonic Agents Endocrinology Diabetes and Metabolism Immunology Population Embryonic Development Biology Fibroblast growth factor General Biochemistry Genetics and Molecular Biology Mice Pregnancy Risk Factors Internal medicine medicine Immunology and Allergy Animals Humans education Promoter Regions Genetic Gene Transcription factor Endocardium Regulation of gene expression Mice Knockout education.field_of_study Embryonic heart Myocardium Promoter Heart TATA Box Rats Fibroblast Growth Factors Endocrinology Gene Expression Regulation Cardiovascular Diseases Codon Nonsense Female |
Zdroj: | Cytokinegrowth factor reviews. 26(1) |
ISSN: | 1879-0305 |
Popis: | Fibroblast growth factor 16 (FGF-16) was originally cloned from rat heart. Subsequent investigation of mouse FGF-16, including generation of null mice, revealed a specific pattern of expression in the endocardium and epicardium, and role for FGF-16 during embryonic heart development. FGF-16 is expressed mainly in brown adipose tissue during rat embryonic development, but is expressed mainly in the murine heart after birth. There is also an apparent switch from limited endocardial and epicardial expression in the embryo to the myocardium in the perinatal period. The FGF-16 gene and its location on the X chromosome are conserved between human and murine species, and no other member of the FGF family shows this pattern of spatial and temporal expression. The human and murine FGF-16 gene promoter regions also share an equivalent location for TATA sequences, as well as adjacent putative binding sites for transcription factors linked to cardiac expression and response to stress. Recent evidence has implicated nonsense mutation of FGF-16 with increased cardiovascular risk, and FGF-16 supplementation with cardioprotection. Here we review the important role of FGF-16 in embryonic heart development, its gene regulation, and evidence for FGF-16 as an endogenous and exogenous cardiac-specific and protective factor in the postnatal heart. Moreover, given the conservation of the FGF-16 gene and its chromosomal location between species, the question of support for a cardiac role in the human population is also considered. |
Databáze: | OpenAIRE |
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