The Phenotype and Genotype Experiment Object Model (PaGE-OM): A Robust Data Structure for Information Related to DNA Variation

Autor: Toshio Kojima, Yasumasa Shigemoto, Martin Senger, Atsuhiro Mukaiyama, Takeshi Tomiki, Matthew Darlison, Mark Woon, Hideaki Sugawara, Haseena Rajeevan, Akihiko Konagaya, Heikki Lehväslaiho, Kimitoshi Naito, Hiroshi Mizushima, David Fredman, Gudmundur A. Thorisson, Juha Muilu, Takashige Oroguchi, Masako Kuroda, Debasis Dash, Ituro Inoue, Albert V. Smith, Anthony J. Brookes
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Zdroj: Human Mutation; Vol 30
Human Mutation
ISSN: 1098-1004
DOI: 10.1002/humu.20973
Popis: Torrents of genotype-phenotype data are being generated, all of which must be captured, processed, integrated, and exploited. To do this optimally requires the use of standard and interoperable "object models," providing a description of how to partition the total spectrum of information being dealt with into elemental "objects" (such as "alleles," "genotypes," "phenotype values," "methods") with precisely stated logical interrelationships (such as "A objects are made up from one or more B objects"). We herein propose the Phenotype and Genotype Experiment Object Model (PaGE-OM; www.pageom.org), which has been tested and implemented in conjunction with several major databases, and approved as a standard by the Object Management Group (OMG). PaGE-OM is open-source, ready for use by the wider community, and can be further developed as needs arise. It will help to improve information management, assist data integration, and simplify the task of informatics resource design and construction for genotype and phenotype data projects.
Databáze: OpenAIRE
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