Impact of Increasing Adiposity in Hyperlipidemic Children
| Autor: | Saul Miller, Nita Chahal, Cedric Manlhiot, Geraldine Cullen-Dean, Brian W. McCrindle, Louise Bannister |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Diet therapy Hyperlipidemias Comorbidity Overweight chemistry.chemical_compound Internal medicine Hyperlipidemia Humans Medicine Child Triglycerides Adiposity Triglyceride medicine.diagnostic_test business.industry medicine.disease Dietary Fats Obesity Lipoproteins LDL Cholesterol Endocrinology chemistry Pediatrics Perinatology and Child Health Female medicine.symptom business Lipid profile Body mass index Lipoprotein |
| Zdroj: | Clinical Pediatrics. 47:679-684 |
| ISSN: | 1938-2707 0009-9228 |
| Popis: | Despite lifestyle management, children with high-risk hyperlipidemias may become overweight, and this may further adversely impact their lipid profile. Regression analysis was used to determine changes over time in adiposity and their association with lipid profiles and other risk factors for hyperlipidemic children followed in a lipid disorder clinic. 184 patients were included. Median age at presentation was 7 years (2-17 years), and median duration of follow-up was 9 years (5-20 years). Mean initial total cholesterol was 6.9 ± 1.6 mmol/L, low-density lipoproteins were 5.2 ± 1.7 mmol/L, high-density lipoproteins were 1.2 ± 0.4 mmol/L, triglycerides were 1.1 ± 0.8 mmol/L, and body mass index z score was +0.4 ± 1.0. A significant increase in body mass index z score (+0.032/year, P < .001) was observed. There was an associated significant increase in total cholesterol and triglyceride levels and decrease in high-density lipoprotein levels over time. Worsening adiposity is prevalent in hyperlipidemic children and adversely affects their lipid profiles and cardiovascular risk. |
| Databáze: | OpenAIRE |
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