Cimetidine and chlorpheniramine in the treatment of chronic idiopathic urticaria: a multi-centre randomized double-blind study
| Autor: | F. Hindley, P.H. Cartwright, C.T.C. Kennedy, H.P. Glenny, Stanley S. Bleehen, M.W. Greaves, M. Hazell, S.E. Thomas, Julia Newton, G.M. Fairiss, N.R. Rowell, R. Marks, K. Howland |
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| Rok vydání: | 1987 |
| Předmět: |
medicine.medical_specialty
Chlorpheniramine Urticaria medicine.drug_class medicine.medical_treatment Dermatology Placebo chemistry.chemical_compound Random Allocation Pharmacotherapy Double-Blind Method medicine Humans Cimetidine Skin Chemotherapy Clinical Trials as Topic business.industry Chlorphenamine Surgery chemistry Anesthesia Itching Drug Therapy Combination medicine.symptom business Histamine H1 antagonist medicine.drug |
| Zdroj: | The British journal of dermatology. 117(1) |
| ISSN: | 0007-0963 |
| Popis: | One hundred and twenty patients with chronic idiopathic urticaria, who entered a study at five centres (Sheffield, London, Bristol, Cardiff and Leeds) were treated with therapeutic doses of the H1 antagonist chlorpheniramine for 6 weeks. Histamine H1 non-responders (40 patients) were entered into a double-blind study and received chlorpheniramine plus cimetidine 400 mg q.d.s. (21 patients) or chlorpheniramine plus placebo (19 patients) for a further 8 weeks. The most important response measure was the change from baseline of the total symptom score: an assessment of the number and duration of new weals and degree of itching. There was a statistically significant difference between the average response in the two treatment groups in favour of chlorpheniramine plus cimetidine after 4 and 8 weeks' treatment (P less than 0.05 and P less than 0.01, respectively). No significant side-effects related to treatment were noted. |
| Databáze: | OpenAIRE |
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