| Autor: |
Jesús Sanz-Sanz, Ángel García-Aparicio, Teresa Diaz-Valle, Israel Thuissard-Vasallo, Julia Fernández-Melón, Maria Del Mar Esteban-Ortega, Santiago Muñoz-Fernández, Nuria Valdés-Sanz, Isabel García-Lozano, Rosalía Méndez-Fernández, Alejandro Javier García-González, David Díaz-Valle, María Gómez-Resa, Bruno Francisco Casco-Silva, Teresa Navío, Martina Steiner, María Gurrea-Almela, Javier Sambricio, Esperanza Pato-Cour, Eugenio Perez-Blazquez, Manuel Moriche-Carretero, Cruz Fernández-Espartero |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
JCR: Journal of Clinical Rheumatology. |
| ISSN: |
1076-1608 |
| DOI: |
10.1097/rhu.0000000000001458 |
| Popis: |
OBJECTIVE Choroidal thickness (CT) has been evaluated as a marker of systemic inflammation in ankylosing spondylitis (AS). This study evaluates the CT of AS patients before and after 6 months of biological treatment. METHODS This longitudinal multicenter study evaluated CT in 44 AS patients. The correlations between CT and C-reactive protein (CRP) with disease activity indices were calculated. The concordance between CT and CRP was determined. We assessed factors associated with response to treatment. Clinically important improvement was defined as a decrease in Ankylosing Spondylitis Disease Activity Score of 1.1 points or greater. RESULTS Forty-four eyes in patients aged 18 to 65 years were included. Mean CT values were significantly higher at baseline than after 6 months of treatment (baseline: 355.28 ± 80.46 μm; 6 months: 341.26 ± 81.06 μm; p < 0.001). There was a 95% concordance between CT and CRP at baseline and 6 months. Clinically important improvement was associated with lower baseline CT and age as independent factors (odds ratios, 0.97 [95% confidence interval, 0.91-0.93; p = 0.009] and 0.81 [95% confidence interval, 0.7-0.95; p = 0.005]), with baseline CT of less than 374 μm (sensitivity 78%, specificity 78%, area under the curve 0.70, likelihood ratio 3.6). CONCLUSIONS Choroidal thickness decreased significantly after 6 months of biological treatment in all treatment groups. Choroidal thickness and CRP had a 95% concordance. A high CT was associated with a risk of biological treatment failure. Choroidal thickness can be considered a useful biomarker of inflammation and a factor associated with response to treatment in AS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
