Impact of Age at the Time of the First ST-Elevation Myocardial Infarction on 10-Year Outcomes (from the EXAMINATION-EXTEND Trial)

Autor: Victor Arévalos, Francesco Spione, Rami Gabani, Luis Ortega-Paz, Josep Gómez-Lara, Víctor Jiménez-Díaz, Marcelo Jiménez, Pilar Jiménez-Quevedo, Roberto Diletti, Javier Pineda, Gianluca Campo, Antonio Silvestro, Jaume Maristany, Xacobe Flores, Loreto Oyarzabal, Guillermo Bastos-Fernandez, Andrés Iñiguez, Antonio Serra, Javier Escaned, Alfonso Ielasi, Maurizio Tespili, Mattie Lenzen, Antonio Fernández-Ortiz, Pascual Bordes, Matteo Tebaldi, Simone Biscaglia, Soheil Al-Shaibani, Rafael Romaguera, Joan Antoni Gómez-Hospital, Josep Rodes-Cabau, Patrick W. Serruys, Manel Sabaté, Salvatore Brugaletta
Přispěvatelé: Cardiology
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: American Journal of Cardiology, 190, 32-40. Elsevier Inc.
ISSN: 1879-1913
0002-9149
DOI: 10.1016/j.amjcard.2022.11.035
Popis: The aim of this substudy of the EXAMINATION-EXTEND was to analyze 10-year outcomes according to the patient's age at the time of the first ST-elevation myocardial infarction (STEMI). Of 1,498 patients with STEMI included in the EXAMINATION-EXTEND study, those with a previous history of coronary ischemic even or ischemic stroke were excluded from this analysis. The remaining 1,375 patients were divided into 4 age groups: 75 years. The primary end point was 10-year patient-oriented composite end point (POCE) of all-cause death, any MI, or any revascularization. At 10-year follow-up, patients aged 75 years, led by a lower incidence of all-cause death (75 years: 61.6%, p = 0.001). Cardiac death was more prevalent in the older group (75 years: 35.5%, p = 0.001). In the landmark analyses, between 5- and 10-year follow-up, young patients exhibited a higher incidence of any revascularization (65 years: 1.6%, p = 0.001). In conclusion, in patients with a first STEMI, advanced age was associated with high rates of POCE at 10-year follow-up due to all-cause and cardiac death. Conversely, younger patients exhibited a high risk of revascularization at long-term follow-up.
Databáze: OpenAIRE
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