Chronic alcohol consumption augments loss of sialic acid residues and alters erythrocyte membrane charge in type II diabetic patients
| Autor: | Güngör Kanbak, Kazim Kartkaya, Serkan Degirmenci, Aysen Akalin |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Alcohol Drinking Health Toxicology and Mutagenesis Neuraminidase Alcohol Toxicology Sialidase Biochemistry Body Mass Index chemistry.chemical_compound Diabetes mellitus Internal medicine Healthy control Mole medicine Humans Molecular Biology Glycated Hemoglobin Erythrocyte Membrane gamma-Glutamyltransferase General Medicine Middle Aged medicine.disease Lipids Chronic alcohol N-Acetylneuraminic Acid Sialic acid Erythrocyte membrane Endocrinology Diabetes Mellitus Type 2 chemistry Case-Control Studies Immunology Molecular Medicine Female |
| Zdroj: | Journal of Biochemical and Molecular Toxicology. 22:320-327 |
| ISSN: | 1099-0461 1095-6670 |
| DOI: | 10.1002/jbt.20243 |
| Popis: | In this study, the effects of alcohol consumption on erythrocyte membrane properties in type 2 diabetic patients were investigated. Therefore, we measured total and lipid-bound sialic acid (LSA) levels, sialidase activities, and erythrocyte membrane negative charge. Three groups, including control group (n = 20), alcohol-consuming diabetic patients group (n = 14), and diabetic patients without alcohol consumption group (n = 42), were created. Plasma total sialic acid (TSA) levels of the alcohol-consuming diabetic group were elevated as compared to the healthy control and diabetic group (p0.001 and p0.01, respectively). TSA levels of the diabetic group were significantly elevated as compared to the healthy control group (p0.001). Plasma LSA levels of the alcohol-consuming diabetic group were higher than that in the healthy control and diabetic group (p0.05 and p0.05, respectively). LSA levels of the diabetic group were found to be high as compared to the healthy control group (p0.05). Plasma sialidase activities of the alcohol-consuming diabetic group and diabetic group were significantly elevated as compared to the healthy control group (p0.05 and p0.05, respectively). Sialidase activities of the alcohol-consuming diabetic group were elevated as compared to the diabetic group, but this was not statistically significant (p0.05). Erythrocyte membrane negativity levels of the alcohol-consuming diabetic group and diabetic group were significantly decreased (p0.001 and p0.001, respectively) as compared to the healthy control group. Erythrocyte membrane negativity levels of the alcohol-consuming diabetic group were decreased as compared to the diabetic group, but this was not statistically significant (p0.05). In conclusion, our results indicate that chronic alcohol consumption may augment membrane alterations in type 2 diabetic patients. |
| Databáze: | OpenAIRE |
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