Molecular and biological characterization of a murine ligand for CD40
| Autor: | Timothy A. Sato, Craig A. Smith, Kenneth H. Grabstein, Edward A. Clark, Terri Davis-Smith, Richard J. Armitage, David Cosman, Laura Strockbine, Brian M. Macduff, Steven D. Gimpel, Dirk M. Anderson, Ky N. Clifford, William C. Fanslow, Charles R. Maliszewski, Melanie K. Spriggs |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.drug_class
T-Lymphocytes Cell CD40 Ligand Molecular Sequence Data Monoclonal antibody Ligands chemistry.chemical_compound Mice Antigens CD Extracellular medicine Tumor Cells Cultured Animals Humans Amino Acid Sequence CD40 Antigens Receptor chemistry.chemical_classification B-Lymphocytes Multidisciplinary CD40 Membrane Glycoproteins biology Base Sequence Tyrosine phosphorylation Immunoglobulin E Molecular biology Antigens Differentiation B-Lymphocyte medicine.anatomical_structure chemistry biology.protein Glycoprotein Intracellular Protein Binding |
| Zdroj: | Nature. 357(6373) |
| ISSN: | 0028-0836 |
| Popis: | THE CD40 surface molecule is a 277-amino-acid glycoprotein expressed on B lymphocytes, epithelial cells and some carcinoma cell lines. Monoclonal antibodies against CD40 mediate a variety of effects on B lymphocytes, including induction of intercellular adhesion1,2, short- and long-term proliferation3–5, differentiation6,7 and enhanced tyrosine phosphorylation of proteins8. In addition, germinal centre centrocytes are prevented from undergoing apop-tosis by activation through CD40 and receptor for antigen9. These data indicate that CD40 could be a receptor for an unknown ligand with important functions in B-cell development and activation. This hypothesis is strengthened by the homology of the extracellular region of the CD40 molecule10with a family of cell-surface glycoproteins11,12that includes the receptors for nerve growth factor13,14 and tumour necrosis factor11,15,16. Here we report the cloning of a ligand for CD40 that is expressed on the cell surface of activated T cells and mediates B-cell proliferation in the absence of co-stimulus, as well as IgE production in the presence of interIeukin-4. |
| Databáze: | OpenAIRE |
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