Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus: Data from the UK Juvenile-onset systemic lupus erythematosus cohort study

Autor:	Valentina Leone, DP Hawley, Michael W. Beresford, Kirsty Haslam, Devesh Mewar, Satyapal Rangaraj, Robert J. Moots, Eslam Al-Abadi, Flora McErlane, Kate Armon, Rolando Cimaz, Gita Modgil, Christian M. Hedrich, Nick Wilkinson, Athimalaipet V Ramanan, Alice Leahy, Clarissa Pilkington, Francesca Pregnolato, Eve Md Smith, Teresa Giani, Joyce Davidson, Coziana Ciurtin, Kathryn Bailey, Janet Gardner-Medwin, Arani Sridhar, Phil Riley
Rok vydání:	2021
Předmět:	Male Adolescent Central nervous system Disease Cohort Studies Systemic lupus erythematosus Rheumatology peripheral nervous system Humans Lupus Erythematosus Systemic Juvenile Medicine Child business.industry Mental Disorders Lupus Vasculitis Central Nervous System central nervous system United Kingdom pediatric juvenile Juvenile onset medicine.anatomical_structure neuropsychiatric Peripheral nervous system Papers Immunology Female business Cohort study
Zdroj:	Lupus
ISSN:	1477-0962 0961-2033
DOI:	10.1177/09612033211045050
Popis:	Introduction Juvenile-onset systemic lupus erythematosus (JSLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Neuropsychiatric (NP) involvement is a severe complication, encompassing a heterogeneous range of neurological and psychiatric manifestations. Methods Demographic, clinical, and laboratory features of NP-SLE were assessed in participants of the UK JSLE Cohort Study, and compared to patients in the same cohort without NP manifestations. Results A total of 428 JSLE patients were included in this study, 25% of which exhibited NP features, half of them at first visit. Most common neurological symptoms among NP-JSLE patients included headaches (78.5%), mood disorders (48.6%), cognitive impairment (42%), anxiety (23.3%), seizures (19.6%), movement disorders (17.7%), and cerebrovascular disease (14.9%). Peripheral nervous system involvement was recorded in 7% of NP-SLE patients. NP-JSLE patients more frequently exhibited thrombocytopenia (9/L) ( p = 0.04), higher C-reactive protein levels ( p = 0.01), higher global pBILAG score at first visit ( p < 0.001), and higher SLICC damage index score at first ( p = 0.02) and last ( p < 0.001) visit when compared to JSLE patients without NP involvement. Conclusions A significant proportion of JSLE patients experience NP involvement (25%). Juvenile-onset NP-SLE most commonly affects the CNS and is associated with increased overall disease activity and damage.
Databáze:	OpenAIRE
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