The evidence of platelet activation in bronchial asthma
| Autor: | Hideaki Yamamoto, Yoshio Sakamoto, Makoto Nagata, Hidenori Kiuchi, Kazuaki Tabe, Keiichiro Yamamoto, Isao Kimura, Yutaka Dohi |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Allergy Adolescent Immunology Provocation test Status Asthmaticus Platelet Factor 4 Bronchial Provocation Tests chemistry.chemical_compound medicine Immunology and Allergy Humans Platelet activation Least-Squares Analysis Platelet Activating Factor Asthma House dust mite Bronchus biology Platelet-activating factor business.industry Middle Aged biology.organism_classification medicine.disease Platelet Activation beta-Thromboglobulin respiratory tract diseases medicine.anatomical_structure chemistry Chronic Disease Female business Platelet factor 4 |
| Zdroj: | The Journal of allergy and clinical immunology. 91(1 Pt 1) |
| ISSN: | 0091-6749 |
| Popis: | The possible involvement of platelets in bronchial asthma was investigated under three different conditions: (1) chronic asthma, (2) bronchial provocation inhaling house dust mite (HDM), and (3) status asthmaticus. Plasma levels of beta-thromboglobulin (beta-TG), platelet factor 4 (PF4), and in part, platelet-activating factor (PAF) were measured. Approximately one third of the subjects with symptomatic or asymptomatic chronic asthma showed an increased level of beta-TG or PF4. Statistically significant differences occurred in beta-TG and PF4 levels only between healthy controls and symptomatic subjects. Five out of six subjects showed no elevation of beta-TG and PF4 during immediate asthmatic response. In two out of nine subjects with status asthmaticus, beta-TG or PF4 was elevated, and statistically significant correlations occurred between the initial level of PAF and that of beta-TG or PF4. Those results suggest that the platelet activation in the circulation is sometimes provoked in asthma, but plasma level of alpha-granule-derived proteins does not reflect the intensity or severity of asthma, and that PAF is likely to be a mediator responsible for the platelet activation. |
| Databáze: | OpenAIRE |
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