IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL
Autor: | Laura Saleh, Hongbin Zhang, Jing Wang, Yanni Gu, Lidan Zhang, Ying Cheng, Tianjiao Tang |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Male
0301 basic medicine Cancer Research Time Factors medicine.medical_treatment Datasets as Topic Disease 0302 clinical medicine IQGAP2 Surgical oncology Prostate Antineoplastic Combined Chemotherapy Protocols Tumor Microenvironment RNA-Seq RC254-282 Oligonucleotide Array Sequence Analysis Prognostic factor Neoplasms. Tumors. Oncology. Including cancer and carcinogens Immunosuppression Middle Aged Prognosis Gene Expression Regulation Neoplastic Treatment Outcome medicine.anatomical_structure Oncology Vincristine ras GTPase-Activating Proteins 030220 oncology & carcinogenesis Female Lymphoma Large B-Cell Diffuse Single-Cell Analysis Rituximab Research Article 03 medical and health sciences Immune system Biomarkers Tumor Genetics medicine Humans Independent factor RNA Messenger Cyclophosphamide Retrospective Studies Messenger RNA Performance status business.industry medicine.disease Survival Analysis Lymphoma 030104 developmental biology Doxorubicin DLBCL Cancer research Prednisone Tumor Escape business |
Zdroj: | BMC Cancer, Vol 21, Iss 1, Pp 1-11 (2021) BMC Cancer |
ISSN: | 1471-2407 |
Popis: | Background Almost one-third of patients with diffuse large B-cell lymphoma (DLBCL) cannot be cured with initial therapy and will eventually succumb to the disease. Further elaboration of prognostic markers of DLBCL will provide therapeutic targets. IQ motif-containing GTPase activating protein 2 (IQGAP2) acts as a tumour suppressor in hepatocellular, prostate, and gastric cancers. However, the role of IQGAP2 in DLBCL remains unclear. Methods We collected mRNA expression data from 614 samples and the corresponding clinical information. The survival time of patients was compared between groups according to the mRNA expression level of IQGAP2. Survival analyses were performed in different subgroups when considering the effect of age, tumour stage, serum lactate dehydrogenase (LDH) concentration, performance status, and the number of extra nodal disease sites. The biological processes associated with IQGAP2-associated mRNAs were analysed to predict the function of IQGAP2. The correlation of IQGAP2 mRNA with immunosuppressive genes and leukocyte infiltration were analysed. Results The overall survival of patients with increased IQGAP2 mRNA levels was reduced even after aggressive treatment independent of age, tumour stage, serum LDH concentration, performance status, and the number of extra nodal disease sites. Furthermore, the biological processes of IQGAP2-associated mRNAs were mainly immune processes. IQGAP2 mRNA expression was correlated with the expression of immunosuppressive genes and leukocyte infiltration. Conclusion IQGAP2 mRNA is an independent prognostic factor and is related to immunosuppression in DLBCL. This discovery may provide a promising target for further development of therapy. |
Databáze: | OpenAIRE |
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