IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL

Autor: Laura Saleh, Hongbin Zhang, Jing Wang, Yanni Gu, Lidan Zhang, Ying Cheng, Tianjiao Tang
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
0301 basic medicine
Cancer Research
Time Factors
medicine.medical_treatment
Datasets as Topic
Disease
0302 clinical medicine
IQGAP2
Surgical oncology
Prostate
Antineoplastic Combined Chemotherapy Protocols
Tumor Microenvironment
RNA-Seq
RC254-282
Oligonucleotide Array Sequence Analysis
Prognostic factor
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Immunosuppression
Middle Aged
Prognosis
Gene Expression Regulation
Neoplastic
Treatment Outcome
medicine.anatomical_structure
Oncology
Vincristine
ras GTPase-Activating Proteins
030220 oncology & carcinogenesis
Female
Lymphoma
Large B-Cell
Diffuse
Single-Cell Analysis
Rituximab
Research Article
03 medical and health sciences
Immune system
Biomarkers
Tumor
Genetics
medicine
Humans
Independent factor
RNA
Messenger
Cyclophosphamide
Retrospective Studies
Messenger RNA
Performance status
business.industry
medicine.disease
Survival Analysis
Lymphoma
030104 developmental biology
Doxorubicin
DLBCL
Cancer research
Prednisone
Tumor Escape
business
Zdroj: BMC Cancer, Vol 21, Iss 1, Pp 1-11 (2021)
BMC Cancer
ISSN: 1471-2407
Popis: Background Almost one-third of patients with diffuse large B-cell lymphoma (DLBCL) cannot be cured with initial therapy and will eventually succumb to the disease. Further elaboration of prognostic markers of DLBCL will provide therapeutic targets. IQ motif-containing GTPase activating protein 2 (IQGAP2) acts as a tumour suppressor in hepatocellular, prostate, and gastric cancers. However, the role of IQGAP2 in DLBCL remains unclear. Methods We collected mRNA expression data from 614 samples and the corresponding clinical information. The survival time of patients was compared between groups according to the mRNA expression level of IQGAP2. Survival analyses were performed in different subgroups when considering the effect of age, tumour stage, serum lactate dehydrogenase (LDH) concentration, performance status, and the number of extra nodal disease sites. The biological processes associated with IQGAP2-associated mRNAs were analysed to predict the function of IQGAP2. The correlation of IQGAP2 mRNA with immunosuppressive genes and leukocyte infiltration were analysed. Results The overall survival of patients with increased IQGAP2 mRNA levels was reduced even after aggressive treatment independent of age, tumour stage, serum LDH concentration, performance status, and the number of extra nodal disease sites. Furthermore, the biological processes of IQGAP2-associated mRNAs were mainly immune processes. IQGAP2 mRNA expression was correlated with the expression of immunosuppressive genes and leukocyte infiltration. Conclusion IQGAP2 mRNA is an independent prognostic factor and is related to immunosuppression in DLBCL. This discovery may provide a promising target for further development of therapy.
Databáze: OpenAIRE
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