Pulse pressure in normotensives: a marker of cardiovascular disease
| Autor: | Stamatios F. Stamatelopoulos, John Lekakis, Christos G Rombopoulos, Dimitris Kostandonis, Spyridon D. Moulopoulos, Theodosis J Vogiazoglou, S. T. Toumanidis, Nikos Zakopoulos, John Kanakakis, Christos Papamichael |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Carotid Artery Diseases Male medicine.medical_specialty Ambulatory blood pressure Heart disease Blood Pressure Cardiomegaly Coronary Disease Severity of Illness Index Coronary artery disease Heart Rate medicine.artery Internal medicine Internal Medicine Humans Medicine cardiovascular diseases Common carotid artery Pulse Aged Ultrasonography Arterial pulse pressure business.industry Middle Aged medicine.disease Pulse pressure Blood pressure Intima-media thickness Cardiovascular Diseases cardiovascular system Cardiology Female business |
| Zdroj: | American Journal of Hypertension. 14:195-199 |
| ISSN: | 0895-7061 |
| DOI: | 10.1016/s0895-7061(00)01268-1 |
| Popis: | The purpose of the present study was to evaluate the relation of the systemic arterial pulse pressure and other parameters derived from the 24-h arterial blood pressure (BP) monitoring to the severity of coronary artery disease, carotid lesions, and left ventricular (LV) mass index in patients without arterial hypertension. One hundred ten patients with known coronary artery disease underwent coronary arteriography, 24-h arterial BP monitoring, and ultrasound imaging of the carotid arteries and the myocardium. Measurements of 24-h arterial BP monitoring (systolic, diastolic, and average BP, pulse pressure, abnormal values of systolic and diastolic BP, and heart rate), the severity of coronary heart disease (Gensini score), intima–media thickness (IMT) of the common carotid artery and LV mass index were determined in all patients. By univariate analysis, only 24-h pulse pressure was significantly related to the severity of coronary artery disease (P < .01), carotid IMT(P < .01), and LV mass index (P < .01). In a multivariate analysis, 24-h pulse pressure was also the best predictor of the severity of coronary lesions (P = .009), carotid IMT (P = .003), and LV mass index (P = .009). Gensini score was related (P < .01) to LV mass index and not to carotid IMT. In conclusion, systemic arterial pulse pressure derived from 24-h arterial BP monitoring is related to coronary artery disease, carotid IMT, and LV mass index independently of age or any other derivative of 24-h arterial BP monitoring, indicating that this parameter could be a marker of global cardiovascular risk. |
| Databáze: | OpenAIRE |
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