Design, synthesis and SAR study of Fluorine-containing 3rd-generation taxoids
| Autor: | Changwei, Wang, Lei, Chen, Yi, Sun, Wanrong, Guo, Adam K, Taouil, Iwao, Ojima |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Dose-Response Relationship
Drug Molecular Structure Cell Survival Organic Chemistry Antineoplastic Agents Fluorine Biochemistry Molecular Docking Simulation Structure-Activity Relationship Drug Design Drug Discovery Tumor Cells Cultured Humans Taxoids Drug Screening Assays Antitumor Molecular Biology Cell Proliferation |
| Zdroj: | Bioorganic Chemistry. 119:105578 |
| ISSN: | 0045-2068 |
| DOI: | 10.1016/j.bioorg.2021.105578 |
| Popis: | It has been shown that the incorporation of fluorine or organofluorine groups into pharmaceutical and agricultural drugs often induces desirable pharmacological properties through unique protein-drug interactions involving fluorine. We have reported separately remarkable effects of the 2,2-difluorovinyl (DFV) group at the C3' position, as well as those of the CF |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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