Enteric Escherichia coli Infections. Morphological Findings in the Intestinal Mucosa of Healthy and Diseased Piglets
| Autor: | M. Hornich, M. Sedláček, Z. Sarmanova, E. Salajka, L. Ulmann |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Diarrhea
0301 basic medicine Time Factors Duodenum Swine 040301 veterinary sciences Crypt Ileum Biology Microbiology 0403 veterinary science Andrology 03 medical and health sciences Intestinal mucosa medicine Animals Germ-Free Life Intestinal Mucosa Escherichia coli Infections Escherichia coli infection Swine Diseases General Veterinary Age Factors 04 agricultural and veterinary sciences Intestinal epithelium Epithelium Small intestine Jejunum 030104 developmental biology medicine.anatomical_structure |
| Zdroj: | Veterinary Pathology. 10:484-500 |
| ISSN: | 1544-2217 0300-9858 |
| Popis: | The villi of the small intestine of healthy conventional pigs were finger-shaped or leaf-shaped. In animals with an acute diarrhoeal form of Escherichia coli infection there was a change in the ratio of villous length to crypt depth but not in the villous shape. In animals with the diarrhoeal E. coli infection of longer duration a remoulding of the villi to a ridge shape occurred at about 20 days of age, but the surface of the mucosa was never flat. At this age the average ratio of villous length to crypt depth for the duodenum, je junum, and ileum, respectively, was 4.0, 5.0 and 4.1 in healthy piglets and 0.5, 0.6 and 0.8 in animals with the diarrhoeal form of E. coli infection. The basic principles of normal renewal of the epithelium of the small intestine have been investigated (3, 5-7, 15, 16,33,38,39). It has been de monstrated that the epithelial cells are formed in production zones of the crypts of Lieberki.ihn and then cease dividing, differentiate and mature on their way to the tips of the villi, and eventually are shed into the intestinal lumen. LEBLOND and WALKER (17) and LEBLOND and MESSIER (15), using radioautographic studies, demonstrated that the epithelial cell turnover in the small intestine of mammals was completed in 3 days. The rate of migration of enterocytes in the small intestine has been re ported to be conditioned by age (9, 10, 18), starvation (12, 23), and other factors. Interesting observations were made by ABRAMS et al. (I) and LESHER et al. (19), who found that the turnover of the intestinal epithelium was con siderably slower in germ-free than in conventional animals. Continued sup pression of epithelial renewal in the intestine was reported to produce short |
| Databáze: | OpenAIRE |
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