Epidemiological investigation and intergenerational clinical characteristics of 24 coronavirus disease patients associated with a supermarket cluster: a retrospective study

Autor:	Mingxin Liu, Yunxia Wang, Xiuli Zou, Jian Han, Wenming Zhang, Kang Ning, Min Wu, Hui Tian, Tiejun Wu, Xihong Zhang, Lina Zhang, Shuangfeng Chen, Guijie Zhou, Junmin Xing, Juan Chen, Suochen Tian, Zhenqin Chang
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Male medicine.medical_specialty Pediatrics China Epidemiology Generation Disease 010502 geochemistry & geophysics 01 natural sciences Asymptomatic Group B 03 medical and health sciences 0302 clinical medicine Severity of illness Medicine Humans 030212 general & internal medicine Supermarkets 0105 earth and related environmental sciences Retrospective Studies Clinical characteristics business.industry SARS-CoV-2 lcsh:Public aspects of medicine Public Health Environmental and Occupational Health Outbreak COVID-19 Retrospective cohort study lcsh:RA1-1270 Cluster Female medicine.symptom Contact Tracing business Contact tracing Research Article
Zdroj:	BMC Public Health, Vol 21, Iss 1, Pp 1-9 (2021) BMC Public Health
ISSN:	1471-2458
Popis:	Background In view of the ongoing coronavirus disease (COVID-19) pandemic, it remains unclear whether the severity of illness and time interval from symptom onset to release from quarantine differ between cases that originated from clusters and cases reported in other areas. This study aimed to assess epidemiological and intergenerational clinical characteristics of COVID-19 patients associated with cluster outbreaks to provide valuable data for the prevention and control of COVID-19. Methods We identified the first employee with COVID-19 at a supermarket and screened the close contacts of this index patient. Confirmed cases were divided into two groups according to the generation (first generation comprising supermarket employees [group A] and second or third generations comprising family members or friends of the supermarket employees [group B]). The epidemiological and clinical characteristics of the two groups were retrospectively compared. Results A total of 8437 people were screened, and 24 COVID-19 patients were identified. Seven patients (29.2%) were asymptomatic; three patients were responsible for six symptomatic cases. The interval from the confirmation of the first case to symptom onset in symptomatic patients was 5–11 days. The clinical manifestations of symptomatic patients upon admission were non-specific. All patients (including the seven asymptomatic patients) were admitted based on chest computed tomography features indicative of pneumonia. There were 11 cases in group A (first generation) and 13 cases in group B (second generation, 11 cases; third generation, 2 cases), with no significant differences in clinical and epidemiological characteristics between the two groups, except for sex, duration from symptom onset to hospitalization, and underlying disease (P > 0.05). Conclusions For cluster outbreaks, it is important to comprehensively screen close the contacts of the index patient. Special attention should be paid to asymptomatic cases. The clinical management of cluster patients is similar to that of other COVID-19 patients.
Databáze:	OpenAIRE
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