Guanosine prevents depressive-like behaviors in rats following bilateral dorsolateral striatum lesion induced by 6-hydroxydopamine
| Autor: | Luisa Bandeira Binder, Rui Daniel Prediger, Naiani Ferreira Marques, Leandra C. Constantino, Carla I. Tasca, Katiane Roversi, Tuane Bazanella Sampaio |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Parkinson's disease Anhedonia Dopamine Nigrostriatal pathway Hippocampus Hippocampal formation Motor Activity Open field Lesion 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Internal medicine medicine Animals Rats Wistar Oxidopamine 030304 developmental biology 0303 health sciences Hydroxydopamine Guanosine business.industry Depression Dopaminergic Brain Parkinson Disease medicine.disease Corpus Striatum Rats Neostriatum Disease Models Animal Endocrinology medicine.anatomical_structure nervous system medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Behavioural brain research. 372 |
| ISSN: | 1872-7549 |
| Popis: | The dorsolateral striatum (DLS) processes motor and non-motor functions and undergoes extensive dopaminergic degeneration in Parkinson’s disease (PD). Beyond the nigrostriatal pathway, dopaminergic degeneration also affects other brain areas including the pre-frontal cortex (PFC) and hippocampus, which have been associated with the appearance of anhedonia and depression at pre-motor phases of PD. Herein, using behavioral and biochemical approaches, we investigated the protective effects of guanosine (GUO) (7.5 mg/kg, i.p.) against emotional impairments and cellular events in cortical, striatal and hippocampal slices of rats submitted to a bilateral infusion of 6-OHDA (10 μg/hemisphere) into the DLS. 6-OHDA-lesioned rats displayed anhedonic- and depressive-like behaviors addressed in the splash and forced swimming tests (at 8 and 21 days after lesion, respectively). In addition, no alterations in motor performance in the open field test and social interaction were observed. Biochemical analyses were performed 22 days after 6-OHDA lesions. 6-OHDA lesion induced hippocampal mitochondrial membrane potential disruption. However, intra-striatal 6-OHDA administration did not alter the ROS levels measured in cortical, striatal and hippocampal slices. GUO treatment attenuated anhedonic- and depressive-like behaviors in 6-OHDA-lesioned rats and protected hippocampal slices against the mitochondrial membrane potential disruption. These results indicate antidepressant-like effects of GUO in a rat model of PD, indicating the potential of GUO for the treatment of depression associated with PD. |
| Databáze: | OpenAIRE |
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