Synthesis and evaluation of isoxazole derivatives as lysophosphatidic acid (LPA) antagonists

Autor:	Chiba Akira, Naoko Ohmuta, Satoshi Iwayama, Chiori Ijichi, Sayaka Asari, Takashi Yamamoto, Yuka Kataba, Koichi Fujita, Masataka Shoji, Yuko Iida, Naoyuki Fukuchi, Koji Ohsumi
Rok vydání:	2006
Předmět:	Stereochemistry Carboxylic acid Chemistry Pharmaceutical Clinical Biochemistry Pharmaceutical Science CHO Cells Biochemistry Chemical synthesis chemistry.chemical_compound Inhibitory Concentration 50 Cricetulus Cricetinae Drug Discovery Lysophosphatidic acid Animals Humans Isoxazole Molecular Biology Cell Proliferation chemistry.chemical_classification Chinese hamster ovary cell Organic Chemistry Isoxazoles Fibrosis In vitro Rats Lysophospholipid receptor chemistry Liver Cell culture Drug Design Molecular Medicine Lysophospholipids Propionates
Zdroj:	Bioorganicmedicinal chemistry letters. 17(13)
ISSN:	0960-894X
Popis:	A series of isoxazole derivatives were synthesized and their antagonistic activities against LPA stimulation on both LPA1/CHO cells and rHSC cells were evaluated. Among them, 3-(4-{4-[1-(2-chloro-cyclopent-1-enyl)-ethoxycarbonylamino]-isoxazol-3- yl}-benzylsulfanyl)-propionic acid (34) showed the most potent activities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b36996856d237f98204ba02aa40785 https://pubmed.ncbi.nlm.nih.gov/17467986 Zobrazit plný text záznamu Full Text from ScienceDirect