Memory CD4 T cells emerge from effector T-cell progenitors
| Autor: | Casey T. Weaver, Karen M. Janowski, James R. Oliver, Laurie E. Harrington, Allan J. Zajac |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
CD4-Positive T-Lymphocytes
Multidisciplinary Effector Stem Cells T cell Mice Transgenic CD8-Positive T-Lymphocytes Biology Acquired immune system Adoptive Transfer Clone Cells Effector T-Lymphocyte Interferon-gamma Mice medicine.anatomical_structure Immunology medicine Animals Cytotoxic T cell Cell Lineage IL-2 receptor Antigens Immunologic Memory Memory T cell CD8 |
| Zdroj: | Nature. 452:356-360 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/nature06672 |
| Popis: | A hallmark of adaptive immunity is the generation of memory T cells that confer long-lived, antigen-specific protection against repeat challenges by pathogens. Understanding the mechanisms by which memory T cells arise is important for rational vaccination strategies and improved therapeutic interventions for chronic infections and autoimmune disorders. The large clonal expansion of CD8 T cells in response to some infections has made the development of CD8 T-cell memory more amenable to study, giving rise to a model of memory cell differentiation in which a fraction of fully competent effector T cells transition into long-lived memory T cells. Delineation of CD4 T-cell memory development has proved more difficult as a result of limitations on tracking the smaller populations of CD4 effector T cells generated during a pathogenic challenge, complicating efforts to determine whether CD4 memory T cells are direct descendants of effector T cells or whether they develop by alternative pathways. Here, using two complementary cytokine reporter mouse models to identify interferon (IFN)-gamma-positive effector T cells and track their fate, we show that the lineage relationship between effector and memory CD4 T cells resembles that for CD8 T cells responding to the same pathogen. We find that, in parallel with effector CD8 T cells, IFN-gamma-positive effector CD4 T cells give rise to long-lived memory T cells capable of anamnestic responses to antigenic rechallenge. |
| Databáze: | OpenAIRE |
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