Urotensin-II Receptor: A Double Identity Receptor Involved in Vasoconstriction and in the Development of Digestive Tract Cancers and other Tumors
| Autor: | Carmela Loguercio, Paolo Grieco, Marcello Dallio, Ettore Novellino, Alessandro Federico, Michele Caraglia, Francesco Merlino, Gabriella Misso, Silvia Zappavigna |
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| Přispěvatelé: | Federico, Alessandro, Zappavigna, Silvia, Dallio, Marcello, Misso, Gabriella, Merlino, Francesco, Loguercio, Carmela, Novellino, Ettore, Grieco, Paolo, Caraglia, Michele, Loguercio, Carmelina, Paolo Grieco, Paolo X |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Cancer Research medicine.medical_specialty Hypertension Pulmonary Urotensins Motility Biology Urotensin-II receptor Receptors G-Protein-Coupled 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Drug Discovery medicine Humans Receptor cancer prognostic marker Cell Proliferation Gastrointestinal Neoplasms Pharmacology Kidney digestive tract cancers Cell growth Prostatic Neoplasms 030104 developmental biology Endocrinology medicine.anatomical_structure Oncology chemistry Urinary Bladder Neoplasms Vasoconstriction 030220 oncology & carcinogenesis Cancer cell Female Urotensin-II |
| Zdroj: | Current cancer drug targets. 17(2) |
| ISSN: | 1873-5576 |
| Popis: | Urotensin II and Urotensin-II receptors are important molecular factors that regulate vasoconstriction and all the diseases that are linked to abnormalities in blood pressure regulation (i.e.: hypertension, kidney diseases, cirrhosis etc.). Recently, Urotensin II and its receptor have also been involved in metabolic syndrome, diabetes and schizophrenia. Recent strong findings suggest that Urotensin II and its receptor are involved in the onset and development of different epithelial cancers. Indeed, it was reported that cell growth, motility and invasion in human breast, bladder, prostate, colorectal and glioblastoma cancer cells were regulated by Urotensin II and Urotensin-II receptor axis. This axis also regulated focal adhesion kinase and small Guanosine-5'-triphosphate binding proteins that likely had a role in motility and invasion mediated by Urotensin-II receptor. Additionally, its expression on tumour tissues is variably associated to the prediction of the clinical outcome of the patients and it can be considered an alternative molecular marker to be used as prognostic factor in human cancers. In conclusion, a new weapon in the treatment of human cancers is highlighting a new scenario for the future. |
| Databáze: | OpenAIRE |
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