Amphiphilic fluorescent probe self-encored in plasma to detect pH fluctuations in cancer cell membranes
| Autor: | Sankarprasad Bhuniya, Kaustabh Kumar Maiti, Sanjib Samanta, Manu M. Joseph, Arup Podder, Shayeri Biswas |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cell
Tumor spheroid Fluorescence Catalysis Cell Line HeLa Surface-Active Agents Neoplasms Amphiphile Materials Chemistry medicine Humans Fluorescent Dyes Molecular Structure biology Chemistry Cell Membrane Metals and Alloys General Chemistry Plasma Hydrogen-Ion Concentration biology.organism_classification Surfaces Coatings and Films Electronic Optical and Magnetic Materials Membrane medicine.anatomical_structure Cancer cell Ceramics and Composites Biophysics |
| Zdroj: | Chemical Communications. 57:607-610 |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | We have developed an amphiphilic pH probe (P1CS) to detect pH levels in the plasma membrane in cancer cells. An elevated fluorescence signal at 550 nm at the cell surface of cancer cells (MDA-MB-231, HeLa cells) prompted the application of P1CS as a pH marker for the cancer cell surface, discriminating it from normal cells (WI-38). Moreover, the probe enables labeling of the surface of multilayered tumor spheroids, which promotes its use as a marker for the surface of tumor tissue. |
| Databáze: | OpenAIRE |
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