Auditory and visual cortical activity during selective attention in fragile X syndrome: A cascade of processing deficiencies

Autor: M.W. Van der Molen, G.J.A. Ramakers, B.C.J. Hamel, M.W. van der Molen, Leopold M. G. Curfs, K.R. Ridderinkhof
Přispěvatelé: Ontwikkelingspsychologie (Psychologie, FMG), Brein en Cognitie (Psychologie, FMG), Klinische Genetica, MUMC+: DA KG Polikliniek (9), Genetica & Celbiologie, RS: CAPHRI School for Public Health and Primary Care, RS: GROW - School for Oncology and Reproduction
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Male
Aging
Visual perception
genetic structures
Visual Physiology
Electroencephalography
Audiology
Neuropsychological Tests
Attention
Oddball paradigm
Evoked Potentials
Visual Cortex
medicine.diagnostic_test
Information processing
Middle Aged
Sensory Systems
Fragile X syndrome
Neurology
Sensation Disorders
Auditory Perception
Evoked Potentials
Auditory
Visual Perception
Regression Analysis
Psychology
ERP
Cognitive psychology
Adult
medicine.medical_specialty
congenital
hereditary
and neonatal diseases and abnormalities
Adolescent
Young Adult
P3b
Physiology (medical)
medicine
Reaction Time
Humans
Auditory Cortex
Modality
N1
medicine.disease
Acoustic Stimulation
Fragile X Syndrome
Evoked Potentials
Visual
Neurology (clinical)
Selective attention
Auditory Physiology
Photic Stimulation
Psychomotor Performance
Zdroj: Clinical Neurophysiology, 123(4), 720-729. Elsevier
Clinical Neurophysiology, 123(4), 720-729. Elsevier Ireland Ltd
ISSN: 1388-2457
DOI: 10.1016/j.clinph.2011.08.023
Popis: Objective: This study examined whether attention deficits in fragile X syndrome (FXS) can be traced back to abnormalities in basic information processing. Method: Sixteen males with FXS and 22 age-matched control participants (mean age 29 years) performed a standard oddball task to examine selective attention in both auditory and visual modalities. Five FXS males were excluded from analysis because they performed below chance level on the auditory task. ERPs were recorded to investigate the N1, P2, N2b, and P3b components. Results: N1 and N2b components were significantly enhanced in FXS males to both auditory and visual stimuli. Interestingly, in FXS males, the P3b to auditory stimuli was significantly reduced relative to visual stimuli. These modality differences in information processing corresponded to behavioral results, showing more errors on the auditory than on the visual task. Conclusions: The current findings suggest that attentional impairments in FXS at the behavioral level can be traced back to abnormalities in event-related cortical activity. These information processing abnormalities in FXS may hinder the allocation of attentional resources needed for optimal processing at higher-levels. Significance: These findings demonstrate that auditory information processing in FXS males is critically impaired relative to visual information processing. Crown Published by Elsevier Ireland Ltd. on behalf of International Federation of Clinical Neurophysiology. All rights reserved.
Databáze: OpenAIRE
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