The role of ISWI chromatin remodeling complexes in brain development and neurodevelopmental disorders
| Autor: | Laura R. Goodwin, David J. Picketts |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adenosine Triphosphatases
Cell Nucleus 0301 basic medicine Zinc finger Cellular differentiation Brain Cell Biology Biology Chromatin Assembly and Disassembly Chromatin Chromatin remodeling Bromodomain Cell biology 03 medical and health sciences Cellular and Molecular Neuroscience 030104 developmental biology Neurodevelopmental Disorders Animals Humans Nucleosome Molecular Biology Neural development Gene Transcription Factors |
| Zdroj: | Molecular and Cellular Neuroscience. 87:55-64 |
| ISSN: | 1044-7431 |
| DOI: | 10.1016/j.mcn.2017.10.008 |
| Popis: | The mammalian ISWI (Imitation Switch) genes SMARCA1 and SMARCA5 encode the ATP-dependent chromatin remodeling proteins SNF2L and SNF2H. The ISWI proteins interact with BAZ (bromodomain adjacent to PHD zinc finger) domain containing proteins to generate eight distinct remodeling complexes. ISWI complex-mediated nucleosome positioning within genes and gene regulatory elements is proving important for the transition from a committed progenitor state to a differentiated cell state. Genetic studies have implicated the involvement of many ATP-dependent chromatin remodeling proteins in neurodevelopmental disorders (NDDs), including SMARCA1. Here we review the characterization of mice inactivated for ISWI and their interacting proteins, as it pertains to brain development and disease. A better understanding of chromatin dynamics during neural development is a prerequisite to understanding disease pathologies and the development of therapeutics for these complex disorders. |
| Databáze: | OpenAIRE |
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