A contribution to the understanding of ocular and cerebrospinal fluid dynamics in astronauts during long-lasting spaceflight
| Autor: | Marijan Klarica, Darko Orešković, Milan Radoš |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
cerebrospinal fluid
ocular fluid dynamics astronauts Long lasting integumentary system genetic structures Cerebrospinal fluid dynamics Intracranial Pressure business.industry Essay General Medicine Space Flight Spaceflight eye diseases nervous system diseases law.invention law Medicine Astronauts Humans sense organs business Neuroscience |
| Zdroj: | Croatian Medical Journal Volume 62 Issue 4 |
| ISSN: | 1332-8166 0353-9504 |
| Popis: | Zhang and Hargens (1) reviewed the knowledge on visual impairment intracranial pressure (VIIP) syndrome in astronauts, a condition that arises as a consequence of long-lasting spaceflight. However, the etiology and pathophysiology of VIIP syndrome remain unclear and only hypothetical. The main reason is the absence of data regarding astronauts’ intracranial (ICP) and intraocular pressure (IOP) during long-lasting spaceflights. It is believed that a crucial role in the pathogenesis of VIIP syndrome is played by chronic ICP/IOP mismatch, which is a consequence of chronically elevated ICP and which results in translaminar pressure gradient. A direct transmission of elevated ICP from the intracranial to the intraocular compartment through the perioptic subarachnoid space should lead to optic nerve sheath distension and disk edema. Therefore, elevated pressure gradient across the lamina cribrosa caused by chronic, gently elevated ICP should finally cause posterior-globe flattening, disk edema, choroid folds, and a hyperoptic shift (1) |
| Databáze: | OpenAIRE |
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