Polypharmacy and bone fracture risk in patients with type 2 diabetes: The Fukuoka Diabetes Registry
| Autor: | Yutaro Oku, Hiroki Fujii, Taiki Higashi, Masahito Yoshinari, Toshiaki Ohkuma, Takanari Kitazono, Udai Nakamura, Masanori Iwase, Wakako Sakamoto, Ayaka Oshiro, Yuji Komorita |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Type 2 diabetes Fractures Bone Endocrinology Bone Density Risk Factors Diabetes mellitus Internal medicine Internal Medicine medicine Humans In patient Registries Aged Polypharmacy Hip Fractures business.industry Hazard ratio General Medicine Bone fracture medicine.disease Confidence interval Diabetes Mellitus Type 2 Cohort Female business |
| Zdroj: | Diabetes Research and Clinical Practice. 181:109097 |
| ISSN: | 0168-8227 |
| DOI: | 10.1016/j.diabres.2021.109097 |
| Popis: | AIMS To prospectively investigate the association between the number of prescribed drugs and the fracture risk in patients with type 2 diabetes. METHODS Japanese participants with type 2 diabetes (n = 4,706; 2,755 men, 1,951 postmenopausal women; mean age, 66 years) were followed for a median of 5.3 years and grouped on the basis of the number of prescribed drugs at baseline. The main outcomes were fractures at any anatomic site and fragility fractures (fractures at hip and spine sites). RESULTS During follow-up, any fracture occurred in 662 participants. The overall age- and sex-adjusted fracture incidence rates per 1,000 person-years were 21.2 (0-2 drugs), 28.1 (3-5 drugs), 37.7 (6-8 drugs), and 44.0 (≥9 drugs) (p for trend |
| Databáze: | OpenAIRE |
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