Fast, asymmetric and nonhomogeneous clearance of SiC nanoaerosol assessed by micro-particle-induced x-ray emission
| Autor: | Omar Lozano, Julien L. Colaux, Julie Laloy, Stéphane Lucas, Lütfiye Alpan, Jean-Michel Dogné |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Materials science Silicon Metabolic Clearance Rate Surface Properties Carbon Compounds Inorganic Biomedical Engineering Analytical chemistry Medicine (miscellaneous) chemistry.chemical_element Bioengineering 02 engineering and technology Particle-induced X-ray emission μPIXE Development Rats Sprague-Dawley 03 medical and health sciences stomatognathic system Animals General Materials Science Tissue Distribution SiC nanoparticles Particle Size Lung Aerosols Particle-induced x-ray emission Micro particles 030111 toxicology Silicon Compounds X-ray Spectrometry X-Ray Emission Biopersistence Rat lungs 021001 nanoscience & nanotechnology Nanostructures Rats chemistry Kurtosis Female 0210 nano-technology |
| Zdroj: | Nanomedicine. 13(2):145-155 |
| ISSN: | 1748-6963 1743-5889 |
| DOI: | 10.2217/nnm-2017-0245 |
| Popis: | Aim: To study the biopersistence of a silicon carbide (SiC) nanoaerosol in rat lungs, as time-dependent clearance and spatial distribution. Materials & methods: Sprague–Dawley rats were exposed 6 h/day during 5 days to a SiC nanoaerosol at 4.91 mg SiC/l. SiC biopersistence in rat lungs sections was assessed over 28 days by micro-particle-induced x-ray emission (μPIXE) as 2D maps and by particle-induced x-ray emission (PIXE) for whole-lung quantification. 2D maps were analyzed for SiC spatial distribution as skewness and kurtosis. Results: Half-time clearance was 10.9 ± 0.9 days, agreeing with PIXE measurements. Spatial-temporal analysis of SiC indicated decreased symmetry and homogeneity. Conclusion: Fast SiC clearance points that current nanoaerosol exposure may not be enough to trigger lung overload. Spatial distribution shows an asymmetric and nonhomogeneous SiC clearance. |
| Databáze: | OpenAIRE |
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