Circulating Plasma MicroRNA-208a as Potential Biomarker of Chronic Indeterminate Phase of Chagas Disease
| Autor: | Alessandra Granato, Celio Geraldo Freire-de-Lima, Leonardo Freire-de-Lima, Roberto Coury Pedrosa, Shana Priscila Coutinho Barroso, Wilson Savino, Elisangela Oliveira de Freitas, Leandra Linhares-Lacerda, Alexandre Morrot, João Francisco Gomes-Neto, Rodrigo Jorge de Alcântara Guerra, Luciana Conde |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Chagas disease medicine.medical_specialty Trypanosoma cruzi lcsh:QR1-502 Disease Microbiology lcsh:Microbiology Muscle hypertrophy Pathogenesis 03 medical and health sciences Internal medicine medicine Myocardial infarction Original Research microRNA business.industry medicine.disease infectious heart disease Chronic infection 030104 developmental biology Heart failure Cardiology Biomarker (medicine) business disease biomarkers |
| Zdroj: | Frontiers in Microbiology, Vol 9 (2018) Frontiers in Microbiology |
| DOI: | 10.3389/fmicb.2018.00269/full |
| Popis: | Chagas cardiomyopathy is the most severe clinical manifestation of chronic Chagas disease. The disease affects most of the Latin American countries, being considered one of the leading causes of morbidity and death in the continent. The pathogenesis of Chagas cardiomyopathy is very complex, with mechanisms involving parasite-dependent cytopathy, immune-mediated myocardial damage and neurogenic disturbances. These pathological changes eventually result in cardiac myocyte hypertrophy, arrhythmias, congestive heart failure and stroke during chronic infection phase. Herein, we show that miR-208a, a microRNA that is a key factor in promoting cardiovascular dysfunction during cardiac hypertrophy processes of heart failure, has its circulating levels increased during chronic indeterminate phase when compared to cardiac (CARD) clinical forms in patients with Chagas disease. In contrast, we have not found altered serum levels of miR-34a, a microRNA known to promote pro-apoptotic role in myocardial infarction during degenerative process of cardiac injuries thus indicating intrinsic differences in the nature of the mechanisms underlying the heart failure triggered by Trypanosoma cruzi infection. Our findings support that the chronic indeterminate phase is a progressive phase involved in the genesis of chagasic cardiopathy and point out the use of plasma levels of miR-208a as candidate biomarker in risk-prediction score for the clinical prognosis of Chagas disease. |
| Databáze: | OpenAIRE |
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