Indoleamine 2,3-Dioxygenase-1 Expression in Adrenocortical Carcinoma
| Autor: | Alyx Vogle, Paolo Gattuso, Brendan M. Finnerty, Rasa Zarnegar, Ritu Ghai, John F. Tierney, Xavier M. Keutgen, Thomas J. Fahey |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Stromal cell Programmed Cell Death 1 Receptor Cell CD8-Positive T-Lymphocytes 03 medical and health sciences Lymphocytes Tumor-Infiltrating 0302 clinical medicine Stroma Antineoplastic Combined Chemotherapy Protocols Adrenocortical Carcinoma Biomarkers Tumor medicine Humans Indoleamine-Pyrrole 2 3 -Dioxygenase Adrenocortical carcinoma Adrenal adenoma Indoleamine 2 3-dioxygenase Immune Checkpoint Inhibitors Retrospective Studies business.industry Programmed Cell Death 1 Ligand 2 Protein medicine.disease Adrenal Cortex Neoplasms medicine.anatomical_structure 030220 oncology & carcinogenesis Adrenal Cortex Cancer research Immunohistochemistry Female 030211 gastroenterology & hepatology Surgery business CD8 |
| Zdroj: | Journal of Surgical Research. 256:90-95 |
| ISSN: | 0022-4804 |
| Popis: | Background Indoleamine 2,3-dioxygenase 1 (IDO-1) is overexpressed in many human carcinomas and a successful target for therapy in mouse models. Prognosis of patients with advanced adrenocortical carcinoma (ACC) is poor due to the lack of effective treatments, and new therapies are therefore needed. Herein, we investigate whether IDO-1 is expressed in human ACC tissues. Methods 53 tissue samples from patients with ACC, adrenal adenoma (AA), adrenocortical tumors (ACTs), and normal adrenal were identified. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded slides for IDO-1. Samples were scored for cytoplasmic staining as per intensity and the percent of positive cells and for stromal staining by percent of positive cells. Tumor characteristics, PD-L1, PDL-2, and CD-8+ T-lymphocyte expression were also determined. Results Samples from 32 ACC, 3 ACT, 15 AA, and 3 normal adrenal were analyzed. IDO-1 was expressed in tumor tissue in 22 of 32 ACC samples, compared with 8 of 15 AA sample (P = 0.344). IDO-1 expression was significantly increased in stromal tissue of ACC samples (16 of 33), compared with AA samples (0 of 15) (P = 0.001). IDO-1 expression in ACC and AA samples was associated with PD-L2 expression (P = 0.034). IDO-1 expression in ACC stromal tissue was associated with CD8+ T-lymphocyte infiltration (P = 0.028). Conclusions IDO-1 is expressed in a majority of ACC samples. Its expression in tumor tissue is associated with PD-L2 expression, and expression in stroma is associated with CD8+ cell infiltration. IDO-1 inhibition, alone or in combination with PD-1 inhibition, could therefore be an interesting target in treatment of ACC. |
| Databáze: | OpenAIRE |
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