From Alpha Diversity to Zzz:Interactions among sleep, the brain, and gut microbiota in the first year of life
| Autor: | Schoch, S F, Castro-Mejía, J L, Krych, L, Leng, B, Kot, W, Kohler, M, Huber, R, Rogler, G, Biedermann, L, Walser, J C, Nielsen, D S, Kurth, S |
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| Přispěvatelé: | University of Zurich |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Infancy
EEG Gut-brain axis Actigraphy Maturation General Neuroscience Brain 610 Medicine & health 10058 Department of Child and Adolescent Psychiatry digestive system Gastrointestinal Microbiome 10219 Clinic for Gastroenterology and Hepatology 10036 Medical Clinic Child Preschool Animals Humans 10178 Clinic for Pneumology Sleep |
| Zdroj: | Schoch, S F, Castro-Mejía, J L, Krych, L, Leng, B, Kot, W, Kohler, M, Huber, R, Rogler, G, Biedermann, L, Walser, J C, Nielsen, D S & Kurth, S 2022, ' From Alpha Diversity to Zzz : Interactions among sleep, the brain, and gut microbiota in the first year of life ', Progress in Neurobiology, vol. 209, 102208 . https://doi.org/10.1016/j.pneurobio.2021.102208 Progress in Neurobiology, 209 |
| ISSN: | 1873-5118 0301-0082 |
| DOI: | 10.1016/j.pneurobio.2021.102208 |
| Popis: | Sleep disorders have been linked to alterations of gut microbiota composition in adult humans and animal models, but it is unclear how this link develops. With longitudinal assessments in 162 healthy infants, we present a so far unrecognized sleep-brain-gut interrelationship. First, we report a link between sleep habits and gut microbiota: daytime sleep is associated with bacterial diversity, and nighttime sleep fragmentation and variability are linked with bacterial maturity and enterotype. Second, we demonstrate a sleep-brain-gut link: bacterial diversity and enterotype are associated with sleep neurophysiology. Third, we show that the sleep-brain-gut link is relevant in development: sleep habits and bacterial markers predict behavioral-developmental outcomes. Our results demonstrate the dynamic interplay between sleep, gut microbiota, and the maturation of brain and behavior during infancy, which aligns with the newly emerging concept of a sleep-brain-gut axis. Importantly, sleep and gut microbiota represent promising health targets since both can be modified non-invasively. As many adult diseases root in early childhood, leveraging protective factors of adequate sleep and age-appropriate gut microbiota in infancy could constitute a health promoting factor across the entire human lifespan. Progress in Neurobiology, 209 ISSN:1873-5118 ISSN:0301-0082 |
| Databáze: | OpenAIRE |
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