Role of glucocorticoids in neutrophil and endothelial adhesion molecule expression and function
| Autor: | Vivienne Talbot, Kevin D. Forsyth |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1992 |
| Předmět: |
Endothelium
Cell adhesion molecule business.industry Immunology Cell Biology Adhesion Cell biology medicine.anatomical_structure Mechanism of action Antigen medicine Chronic inflammatory response cardiovascular system lcsh:Pathology medicine.symptom business Function (biology) Dexamethasone medicine.drug Research Article lcsh:RB1-214 |
| Zdroj: | Mediators of Inflammation, Vol 1, Iss 2, Pp 101-106 (1992) Mediators of Inflammation |
| ISSN: | 1466-1861 0962-9351 |
| Popis: | Glucocorticoids are very effective inhibitors of both the acute and chronic inflammatory response. In this study the hypothesis that glucocorticoids inhibit an early component of the inflammatory response, neutrophil adhesion to endothelium, by down-regulation of adhesion molecules on neutrophils or endothelium was examined. No effect of dexamethasone on neutrophil adhesion to endothelium or of antigen expression by neutrophils or endothelium was found. The mechanism of action of glucocorticoids in the inflammatory response is probably not mediated by alterations in adhesion molecules. |
| Databáze: | OpenAIRE |
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