5-HT1-like receptor agonists enhance wakefulness
| Autor: | Pramod R. Saxena, O.E. Ukponmwan, M.R. Dzoljic |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Agonist Serotonin medicine.medical_specialty Indoles medicine.drug_class Sleep REM Propranolol Pharmacology Piperazines Cellular and Molecular Neuroscience Internal medicine medicine Prazosin Animals heterocyclic compounds Rats Wistar Wakefulness Receptor 8-Hydroxy-2-(di-n-propylamino)tetralin Dose-Response Relationship Drug Chemistry musculoskeletal neural and ocular physiology Antagonist Receptor antagonist Rats Endocrinology nervous system Mechanism of action Receptors Serotonin Serotonin Antagonists medicine.symptom Cyanopindolol Sleep medicine.drug |
| Zdroj: | Neuropharmacology. 31:623-633 |
| ISSN: | 0028-3908 |
| DOI: | 10.1016/0028-3908(92)90140-k |
| Popis: | The effects of four 5-HT1-like receptor agonists (8-OH-DPAT, RU 24969, BEA 1654 and 5-carboxamidotryptamine) and some putative 5-HT1-like receptor antagonists on vigilance were examined in an attempt to clarify the role of 5-HT1-like receptors in the sleep-waking pattern of rats. Both 8-OH-DPAT (0.5–2.0 mg/kg, s.c.) and RU 24969 (0.5–2.0 mg/kg, s.c.) increased wakefulness and the latencies of slow wave and rapid eye movement (REM) sleep. The slow wave and REM sleep were correspondingly decreased or completely abolished. The two other 5-HT1-like receptor agonists had either a slight (BEA 1654, 1.0–5.0 mg/kg, s.c.) or no (5-carboxamidotryptamine, 0.5–2.0 mg/kg, s.c.) effect on sleep pattern. The arousal effect of 8-OH-DPAT was further potentiated in rats pretreated with reserpine (2.5 mg/kg, i.p.; 18 hr before 8-OH-DPAT). The non-selective 5-HT1-like and 5-HT2 receptor antagonist, methiothepin (2.0 mg/kg, i.p.) and the β-adrenoceptor antagonist propranolol (16.0 mg/kg, s.c.), which is a putative antagonist at 5-HT1A and 5-HT1B receptor subtypes, significantly potentiated the arousal effect of RU 24969. The putative 5-HT1A and 5-HT1B receptor antagonist, cyanopindolol (4.0 mg/kg, s.c.), mixed 5-HT1A receptor agonist/antagonist MDL 72832 (1.0 mg/kg, s.c.) and the α1-adrenoceptor antagonist prazosin (2.0 mg/kg) did not affect the vigilance, altered by RU 24969. These results suggest that the arousal effect of 5-HT1-like receptor agonists is probably not mediated by any of the subtypes of 5-HT1-like receptors or by an activation of a noradrenergic system. |
| Databáze: | OpenAIRE |
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