Cyclical intravenous clodronate in postmenopausal osteoporosis: Results of a long-term Clinical trial
| Autor: | S. Boldrini, G. Policani, S. Troiani, C. Massoni, S. Cristallini, E. Rizzello, F Gregorio, L. Fedeli, Paolo Filipponi |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
medicine.medical_specialty Histology Bone disease Bone density Physiology Endocrinology Diabetes and Metabolism Osteoporosis Drug Administration Schedule Bone Density Internal medicine medicine Humans Infusions Intravenous Aged Retrospective Studies Bone mineral business.industry Incidence Incidence (epidemiology) Retrospective cohort study Middle Aged medicine.disease Surgery Clinical trial Spinal Fractures Clodronic acid Female Clodronic Acid business Follow-Up Studies medicine.drug |
| Zdroj: | Bone. 18:179-184 |
| ISSN: | 8756-3282 |
| DOI: | 10.1016/8756-3282(95)00442-4 |
| Popis: | We report the results of long-term cyclical clodronate therapy (200 mg IV infusion every 3 weeks) on 235 women with postmenopausal osteoporosis recruited over 6 years. A retrospective analysis of clinical and instrumental findings in 183 postmenopausal osteoporotic patients was used as control data. Clodronate was well-tolerated and compliance was good. Bone mineral density (BMD) increased significantly and the upward trend persisted for all 6 years of therapy (5.69 +/- 0.184%) vs. controls: -1.47% +/- 0.813%, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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