Polymorphic reticulosis is a neoplasm of large granular lymphocytes with CD3+ phenotype
| Autor: | Teiichi Yamamura, Masahiko Ohsawa, Katsuyuki Aozasa, Yasuhiko Tomita, Shinichi Tagawa |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Herpesvirus 4 Human CD3 Complex CD3 T-Lymphocytes Molecular Sequence Data Nose Neoplasms Genome Viral Biology medicine.disease_cause Lymphoma T-Cell Extranodal NK/T-cell lymphoma nasal type Nose neoplasm Polymerase Chain Reaction Immunophenotyping medicine Humans Lymph node Lymphatic Diseases Granuloma Lethal Midline In Situ Hybridization Base Sequence Histology Middle Aged medicine.disease Lethal midline granuloma Epstein–Barr virus Immunohistochemistry Microscopy Electron medicine.anatomical_structure Oncology biology.protein Female |
| Zdroj: | Cancer. 75(3) |
| ISSN: | 0008-543X |
| Popis: | Background. Polymorphic reticulosis, a type of lethal midline granuloma (LMG), has been referred to as nasal T-cell lymphoma (NTL) because of its proliferating cells' positive reactivity to anti-T-lymphocyte antibodies. Recently, several studies have suggested that proliferating cells in NTL may be natural killer (NK) in nature. NK cells and human non major histocompatibility-restricted cytotoxic T-lymphocytes have the morphology of large granular lymphocytes (LGL) (i.e., a high cytoplasmic: nuclear ratio and cytoplasmic granules). Whether NTL-LMG possesses an LGL morphology is examined in this study. Methods. Two lymph node smears, peripheral blood showing a leukemic picture, and an electron microscope (EM) examination of a cutaneous lesion, respectively, were obtained from four patients with NTL-LMG. Immunohistochemical examination of the proliferating cells and of the Epstein-Barr virus (EBV) genome by both polymerase chain reaction and in situ hybridization also were performed. Results. All patients presented with necrotic and granulomatous lesions in the upper respiratory tract. Histology showed polymorphous cellular infiltrates containing large atypical cells with positive reaction to CD3 (three patients), CD43 (two patients), CD45RO (two patients), and OPD4 (one patient). Imprint smears revealed azurophilic large membrane-delimited granules in an ample cytoplasm, which was confirmed by EM. The presence of the EBV genome in the tumor cells was observed in one patient. Conclusion. The current findings showed that NTLLMG or polymorphic reticulosis is a proliferation of LGL with a CD3 + phenotype |
| Databáze: | OpenAIRE |
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