A simple method for assessing intestinal inflammation in Crohn's disease
| Autor: | Russell Foster, A Roseth, G Sigthorsson, Magne K. Fagerhol, J A Tibble, K Teahon, B Thjodleifsson, R Sherwood, Ingvar Bjarnason, S Bridger |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent CD59 Antigens Colonic Diseases Functional Sensitivity and Specificity Gastroenterology Inflammatory bowel disease Article Diagnosis Differential Excretion Feces fluids and secretions Crohn Disease Internal medicine Biopsy medicine Humans Prospective Studies Prospective cohort study Irritable bowel syndrome Aged Aged 80 and over Crohn's disease medicine.diagnostic_test business.industry Indium Radioisotopes Reproducibility of Results Middle Aged medicine.disease Faecal calprotectin Cross-Sectional Studies Female Calprotectin business Biomarkers |
| Zdroj: | Gut. 47:506-513 |
| ISSN: | 0017-5749 |
| DOI: | 10.1136/gut.47.4.506 |
| Popis: | BACKGROUND AND AIMS—Assessing the presence and degree of intestinal inflammation objectively, simply, and reliably is a significant problem in gastroenterology. We assessed faecal excretion of calprotectin, a stable neutrophil specific marker, as an index of intestinal inflammation and its potential use as a screening test to discriminate between patients with Crohn's disease and those with irritable bowel syndrome. METHODS—The validity of faecal calprotectin as a marker of intestinal inflammation was assessed in 22 patients with Crohn's disease (35 studies) by comparing faecal excretions and concentrations using four day faecal excretion of 111indium white cells. A cross sectional study assessed the sensitivity of faecal calprotectin concentration for the detection of established Crohn's disease (n=116). A prospective study assessed the value of faecal calprotectin in discriminating between patients with Crohn's disease and irritable bowel syndrome in 220 patients referred to a gastroenterology clinic. RESULTS—Four day faecal excretion of 111indium (median 8.7%; 95% confidence interval (CI) 7-17%; normal |
| Databáze: | OpenAIRE |
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