PDR-1/hParkin negatively regulates the phagocyosis of apoptotic cell corpses in Caenorhabditis elegans

Autor: Cabello, J., Sämann, J., Gómez-Orte, E., Erazo, Tatiana, Coppa, A., Pujol, Aurora, Büssing, I, Schulze, B., Lizcano de Vega, José Miguel, Ferrer, I, Baumeister, R., Dalfo, Esther
Přispěvatelé: Universitat de Barcelona
Rok vydání: 2014
Předmět:
0301 basic medicine
rac1 GTP-Binding Protein
Cancer Research
proteasomal degradation
Engulfment
Cell
Homeòstasi
Apoptosis
Proteasomal degradation
Cell Movement
Homeostasis
Small GTPase
Cytoskeleton
Tissue homeostasis
Caenorhabditis elegans
Cell biology
rac GTP-Binding Proteins
medicine.anatomical_structure
Mort cel·lular
C. elegans
Original Article
Proteasome Inhibitors
Rac1
Signal Transduction
Cell death
Programmed cell death
Proteasome Endopeptidase Complex
Ubiquitin-Protein Ligases
Immunology
RAC1
Biology
Transfection
03 medical and health sciences
Cellular and Molecular Neuroscience
Phagocytosis
medicine
Animals
Humans
Caenorhabditis elegans Proteins
Parkin
Cell growth
Ubiquitination
Cell Biology
biology.organism_classification
030104 developmental biology
HEK293 Cells
engulfment
Mutation
Proteolysis
Zdroj: Dipòsit Digital de la UB
Universidad de Barcelona
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Cell Death & Disease
Recercat. Dipósit de la Recerca de Catalunya
instname
Popis: Apoptotic cell death is an integral part of cell turnover in many tissues, and proper corpse clearance is vital to maintaining tissue homeostasis in all multicellular organisms. Even in tissues with high cellular turnover, apoptotic cells are rarely seen because of efficient clearance mechanisms in healthy individuals. In Caenorhabditis elegans, two parallel and partly redundant conserved pathways act in cell corpse engulfment. The pathway for cytoskeletal rearrangement requires the small GTPase CED-10 Rac1 acting for an efficient surround of the dead cell. The CED-10 Rac pathway is also required for the proper migration of the distal tip cells (DTCs) during the development of the C. elegans gonad. Parkin, the mammalian homolog of the C. elegans PDR-1, interacts with Rac1 in aged human brain and it is also implicated with actin dynamics and cytoskeletal rearrangements in Parkinsons's disease, suggesting that it might act on engulfment. Our genetic and biochemical studies indicate that PDR-1 inhibits apoptotic cell engulfment and DTC migration by ubiquitylating CED-10 for degradation.
Databáze: OpenAIRE
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